Tetramethylammonium acetate synthesis
- Product Name:Tetramethylammonium acetate
- CAS Number:10581-12-1
- Molecular formula:C6H15NO2
- Molecular Weight:133.19
75-59-2
64-19-7
10581-12-1
General procedure for the synthesis of tetramethylammonium acetate from tetramethylammonium hydroxide and glacial acetic acid: 247 mg (4.11 mmol) of glacial acetic acid and 1.50 g (4.11 mmol) of tetramethylammonium hydroxide (25% wt. of methanol solution) were dissolved in 10 mL of methanol. The reaction mixture was stirred at 40°C for 4 hours. Upon completion of the reaction, the reaction solution was filtered and the solvent was subsequently removed using a rotary evaporator to give a viscous oil which gradually solidified. The residual trace solvent was removed under high vacuum to give a white solid product. The white solid was washed with ether and subsequently dried under vacuum to give 480 mg of white solid tetramethylammonium acetate in 87.6% yield.
75-59-2
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10581-12-1
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Yield:10581-12-1 87.6%
Reaction Conditions:
in methanol at 40; for 4 h;
Steps:
[NMe4][Acetate] [12]; Used in CORM-349This is commercially available, but earliest reference found in [12].247 mg (4.11 mmol) of acetic acid and 1.50 g (4.11 mmol) of [NMe4][OH] (25 wt. % soln. in MeOH) were stirred in 10 ml of methanol for 4 hrs at 40° C. Following this, the solution was filtered and then the solvent removed on rotary evaporator to give a viscous oil, in which solid was starting to form. The last traces of solvent were removed under high vacuum to leave a white solid, which was washed with ether and then dried under vacuum.480 mg of a white solid were produced. Yield was 87.6%.
References:
Motterlini, Roberto Angelo;Mann, Brian Ernest;Scapens, David Alistair US2010/105770, 2010, A1 Location in patent:Page/Page column 12
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616-38-6
725 suppliers
$5.00/5 g
10581-12-1
220 suppliers
$9.00/25g