Trifluoroacetamide synthesis
- Product Name:Trifluoroacetamide
- CAS Number:354-38-1
- Molecular formula:C2H2F3NO
- Molecular Weight:113.04
10.1142/S1088424621500292
383-63-1
498 suppliers
$10.00/25g
354-38-1
410 suppliers
$6.00/10g
Yield:354-38-1 100%
Reaction Conditions:
with hydrogenchloride;triethylamine in ethanol;ethyl acetate;
Steps:
5 Synthesis of Atropisomeric Trifluoroacetamide 3a
Example 5 Synthesis of Atropisomeric Trifluoroacetamide 3a Atropisomer 2a as the sulfate salt (0.93 gm, 1.84 mmoles, 503.4 MW) was dissolved in 15 ml ethanol. Triethylamine (1.8 ml, 13 mmoles) and ethyl trifluoroacetate (2.2 ml, 18 mmoles) were slowly added (FIG. 2a). The mixture was stirred at room temperature under argon for 2.5 hours. Volatiles were removed under vacuum and the resulting residue was dissolved in 300 ml ethyl acetate and washed with 2*50 ml of 5% HCl. The ethyl acetate fraction was dried over anhydrous Na2SO4, filtered and concentrated under vacuum to yield atropisomeric trifluoroacetamide 3a as an orange solid (0.92 gm, 100% yield, 501.4 MW). 1H NMR (methanol-d4) δ8.35, 1H, d; 8.15, 1H, d; 7.80, 1H, s; 6.82, 1H, s; 6.65, 4H, m; 4.82, 2H, s.
References:
US6448407,2002,B1
354-34-7
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inquiry
354-38-1
410 suppliers
$6.00/10g
79-37-8
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$17.67/10gm:
5875-25-2
83 suppliers
$20.00/1g
354-38-1
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$6.00/10g
76-05-1
719 suppliers
$9.00/1g
354-38-1
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$6.00/10g
14618-49-6
15 suppliers
$52.20/5ml
354-38-1
410 suppliers
$6.00/10g