Xylazine synthesis
- Product Name:Xylazine
- CAS Number:7361-61-7
- Molecular formula:C12H16N2S
- Molecular Weight:220.33
87-62-7
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7361-61-7
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Yield:7361-61-7 113.8 g (84%)
Reaction Conditions:
with acetic anhydride in tetrahydrofuran;ethanol;
Steps:
I EXAMPLE I
EXAMPLE I Xylazine was prepared by a synthesis that comprised the following steps 1, 2 and 3: STR3 To a solution of 2,6-dimethylaniline (100 g. 0.826 mole) in 100 ml of tetrahydrofuran was added acetic anhydride (204 g, 2.0 moles) dropwise over a 1.5 hr period. After a brief induction period, the reaction became exothermic, and at the end of the addition the temperature of the reaction mixture was 60° C. The mixture was stirred 0.5 hr and poured into ice water. The precipitate was collected by filtration, and recrystallization from 300 ml of ethanol gave 113.8 g (84%) of product, m.p. 179°-181° C. (lit. m.p. 180°-181° C.).
References:
US4614798,1986,A
2198-53-0
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7361-61-7
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$27.00/1g