112275-50-0
112275-50-0 結(jié)構(gòu)式
基本信息
1-BOC-單哌嗪
1,4-二氮雜環(huán)庚烷-1-甲酸叔丁酯
1-BOC-1,4-二氮雜環(huán)庚烷
1-N-BOC-高哌嗪
1,4-二氮雜庚烷-1-羧酸叔丁酯
1-BOC-1,4-DIAZEPANE
1-BOC-HEXAHYDRO-1,4-DIAZEPINE
1-BOC-HOMOPIPERAZINE
1-(TERT-BUTOXYCARBONYL)HOMOPIPERAZINE
BOC-HOMOPIPERAZINE
BOC-HOPAZ
BOC-HOPIZ
BUTTPARK 27\08-71
HPBOC
N-(T-BUTYLOXYCARBONYL)-HOMOPIPERAZINE
N-(TERT-BUTOXYCARBONYL)HOMOPIPERAZINE
N-(TERT-BUTYLOXYCARBONYL)-HOMOPIPERAZINE
TERT-BUTYL 1,4-DIAZEPANE-1-CARBOXYLATE
TERT-BUTYL 1-HOMOPIPERAZINECARBOXYLATE
TERT-BUTYL HOMOPIPERAZINE-1-CARBOXYLATE
1-(tert-Butoxycarbonyl)homopiperazine~tert-Butyl hexahydro-1,4-diazepine-1-carboxylate
Tert-butylhexahydro-1,4-diazepine-1-carboxylate
N-TERT-BUTYL-1-HOMOPIPERAZINE CARBOXYLATE
1-BOC-HOMOPIPERAZINE 98%
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
Skin Irrit. 2
STOT SE 3
制備方法
505-66-8
24424-99-5
112275-50-0
在室溫條件下，將1,4-二氮雜環(huán)庚烷（1.0 g，9.780 mmol）的乙酸（9.8 mL）溶液緩慢滴加到二碳酸二叔丁酯（2.201 g，9.780 mmol）的乙酸（9.8 mL）溶液中。反應(yīng)混合物在室溫下攪拌24小時。反應(yīng)完成后，向混合物中加入水，并用10% NaOH溶液調(diào)節(jié)pH至10。隨后，用二氯甲烷（2×15 mL）萃取水相，合并有機相并用無水硫酸鈉干燥。減壓濃縮除去溶劑，得到1,4-二氮雜環(huán)庚烷-1-羧酸叔丁酯，產(chǎn)率為90.0%。產(chǎn)物為液體，其紅外光譜（IR）特征吸收峰（νmax, cm?1）為：2932, 2514, 1681, 1477, 1411, 1166, 991, 769（參見圖4）。
參考文獻：
[1] Patent: EP2578588, 2013, A1. Location in patent: Paragraph 0110; 0111
[2] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 16, p. 6143 - 6148
[3] Patent: US2016/168156, 2016, A1. Location in patent: Paragraph 0592; 0593
[4] Patent: US2003/216375, 2003, A1
[5] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 17, p. 5493 - 5497
知名試劑公司產(chǎn)品信息
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2026/03/03 | L17728 | 1-Boc-單哌嗪, 98% 1-Boc-homopiperazine, 98% | 112275-50-0 | 5g | 945元 |
| 2026/03/03 | 39953 | 1-Boc-單哌嗪 1-BOC-hexahydro-1,4-diazepine, 98%, Thermo Scientific Chemicals | 112275-50-0 | 5g | 1587元 |
| 2025/12/22 | B6228 | 1-(叔丁氧羰基)高哌嗪 1-(tert-Butoxycarbonyl)homopiperazine | 112275-50-0 | 1G | 100元 |