128811-48-3
128811-48-3 結(jié)構(gòu)式
基本信息
R-N-BOC-焦谷氨酸甲酯
N-BOC-D-焦谷氨酸甲酯
N-叔丁氧羰基-D-焦谷氨酸甲酯
N-叔丁氧羰基-L-焦谷氨酸甲酯
1-BOC-5-氧代-D -脯氨酸甲酯
(R)-N-BOC-5-甲氧羰基-2 - 吡咯烷酮
(R)-1-叔丁基2-甲基5-氧代吡咯烷-1,2-二羧酸酯
BOC-D-焦谷氨酸甲酯(CAS號:128811-48-3)
1-叔-丁基 2-甲基 (2R)-5-氧亞基吡咯烷-1,2-二甲酸基酯
1-tert-butyl 2-methyl (2R)-5-oxopyrrolidine-1,2-dicarboxylate
utamic Acid MethyL
1-Boc-5-oxo-D-proline Methyl ester
Boc-L-pyroglutamic acid methyl ester
Boc-D-Pyroglutamic acid methyl ester
(R)-N-(tert-butoxycarbonyl)pyroglutaMate
(R)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE
(R)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE USP/EP/BP
-1-tert-Butyl 2-methyl 5-oxopyrrolidine-1,2-dicarboxylate
物理化學(xué)性質(zhì)
制備方法
24424-99-5
68766-96-1
144978-12-1
以二碳酸二叔丁酯和D-焦谷氨酸乙酯為原料合成BOC-L-焦谷氨酸乙酯的一般步驟：將D-焦谷氨酸乙酯（5.1g，32.6mmol）溶于二氯甲烷（70ml）中，依次加入三乙胺（4.55ml，32.6mmol）、二碳酸二叔丁酯（14.2g，65.2mmol）和4-（二甲基氨基）吡啶（3.98g，32.6mmol）。將反應(yīng)混合物在室溫下攪拌1.5小時，通過薄層色譜（TLC）監(jiān)測反應(yīng)進(jìn)程，確認(rèn)反應(yīng)完全。反應(yīng)完成后，將反應(yīng)液用水洗滌兩次，再用鹽水洗滌，有機(jī)相用無水硫酸鈉干燥，過濾后減壓濃縮。粗產(chǎn)物通過柱色譜法（洗脫劑比例為1:1的乙酸乙酯/石油醚）純化，得到Boc-D-焦谷氨酸乙酯，為淺黃色粘稠油狀物（7.98g，收率95%），靜置后固化為固體。
參考文獻(xiàn)：
[1] Patent: WO2007/36730, 2007, A1. Location in patent: Page/Page column 120
[2] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 4, p. 1383 - 1393
[3] Patent: EP1847536, 2007, A1. Location in patent: Page/Page column 28
[4] Patent: US2009/48213, 2009, A1. Location in patent: Page/Page column 70-71
[5] Patent: US2011/34469, 2011, A1. Location in patent: Page/Page column 124
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/05/22 | XW1288114833 | BOC-D-焦谷氨酸甲酯 methyl n-(tert-butoxycarbonyl)-d-pyroglutamate;n-(tert-butoxycarbonyl)-d-pyroglutamic acid methyl ester;methyl (r)-n-(tert-butoxycarbonyl)pyroglutamate;methyl (r)-1-(tert-butoxycarbonyl)-5-oxopyrrolidine-2-carboxylate;methyl (r)-1-boc-5-oxopyrrolidine-2-carboxylate;(r)-1-boc-5-oxopyrrolidine-2-carboxylic acid methyl ester;(r)-1-(tert-butoxycarbonyl)-5-oxopyrrolidine-2-carboxylic acid methyl ester;boc-d-pyroglutamic acid methyl ester;methyl n-boc-d-pyroglutamate;n-boc-d-pyroglutamic acid methyl ester;1-boc-5-oxo-d-proline methyl ester;(r)-1-tert-butyl 2-methyl 5-oxopyrrolidine-1,2-dicarboxylate;boc-d-pyr-ome | 128811-48-3 | 5G | 46元 |
| 2025/05/22 | XW1288114832 | BOC-D-焦谷氨酸甲酯 methyl n-(tert-butoxycarbonyl)-d-pyroglutamate;n-(tert-butoxycarbonyl)-d-pyroglutamic acid methyl ester;methyl (r)-n-(tert-butoxycarbonyl)pyroglutamate;methyl (r)-1-(tert-butoxycarbonyl)-5-oxopyrrolidine-2-carboxylate;methyl (r)-1-boc-5-oxopyrrolidine-2-carboxylate;(r)-1-boc-5-oxopyrrolidine-2-carboxylic acid methyl ester;(r)-1-(tert-butoxycarbonyl)-5-oxopyrrolidine-2-carboxylic acid methyl ester;boc-d-pyroglutamic acid methyl ester;methyl n-boc-d-pyroglutamate;n-boc-d-pyroglutamic acid methyl ester;1-boc-5-oxo-d-proline methyl ester;(r)-1-tert-butyl 2-methyl 5-oxopyrrolidine-1,2-dicarboxylate;boc-d-pyr-ome | 128811-48-3 | 1G | 32元 |
| 2025/05/22 | XW1288114831 | BOC-D-焦谷氨酸甲酯 methyl n-(tert-butoxycarbonyl)-d-pyroglutamate;n-(tert-butoxycarbonyl)-d-pyroglutamic acid methyl ester;methyl (r)-n-(tert-butoxycarbonyl)pyroglutamate;methyl (r)-1-(tert-butoxycarbonyl)-5-oxopyrrolidine-2-carboxylate;methyl (r)-1-boc-5-oxopyrrolidine-2-carboxylate;(r)-1-boc-5-oxopyrrolidine-2-carboxylic acid methyl ester;(r)-1-(tert-butoxycarbonyl)-5-oxopyrrolidine-2-carboxylic acid methyl ester;boc-d-pyroglutamic acid methyl ester;methyl n-boc-d-pyroglutamate;n-boc-d-pyroglutamic acid methyl ester;1-boc-5-oxo-d-proline methyl ester;(r)-1-tert-butyl 2-methyl 5-oxopyrrolidine-1,2-dicarboxylate;boc-d-pyr-ome | 128811-48-3 | 250MG | 30元 |