1320288-19-4
中文名稱
UNC 0631
英文名稱
UNC 0631
CAS
1320288-19-4
分子式
C37H61N7O2
分子量
635.93
MOL 文件
1320288-19-4.mol
更新日期
2024/11/15 18:20:32
1320288-19-4 結(jié)構(gòu)式
基本信息
中文別名
G9A抑制劑(UNC 0631)N-[1-(環(huán)己基甲基)-4-哌啶基]-2-[六氫-4-異丙基-1H-1,4-二氮雜卓-1-基]-6-甲氧基-7-[3-(1-哌啶基)丙氧基]-4-喹唑啉胺
英文別名
CS-793UNC 0631
UNC 0631, >=98%
UNC0631/UNC-0631
UNC 0631 USP/EP/BP
UNC0631
UNC 0631
UNC-0631
N-[1-(Cyclohexylmethyl)-4-piperidinyl]-2-(4-isopropyl-1,4-diazepa n-1-yl)-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine
N-(1-(cyclohexylmethyl)piperidin-4- yl)-2-(4-isopropyl-1,4-diazepan-1-yl)- 6-methoxy-7-(3-(piperidin-1- yl)propoxy)quinazolin-4-amine
N-[1-(CyclohexylMethyl)-4-piperidinyl]-2-[hexahydro-4-(1-Methylethyl)-1H-1,4-diazepin-1-yl]-6-Methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinaMine
4-Quinazolinamine, N-[1-(cyclohexylmethyl)-4-piperidinyl]-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-
所屬類別
生物化工：Histone Methyltransferase 抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)763.4±70.0 °C(Predicted)
密度1.114±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度insoluble in H2O; ≥12.66 mg/mL in EtOH with ultrasonic; ≥18.35 mg/mL in DMSO with gentle warming
酸度系數(shù)(pKa)9.34±0.70(Predicted)
形態(tài)固體
顏色Light yellow to yellow
UNC 0631價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/12/22 | HY-13808 | UNC 0631 | 1320288-19-4 | 1 mg | 300元 |
| 2025/12/22 | HY-13808 | UNC 0631 UNC 0631 | 1320288-19-4 | 5mg | 750元 |
| 2025/12/22 | HY-13808 | UNC 0631 UNC 0631 | 1320288-19-4 | 10mM * 1mLin DMSO | 1049元 |
常見(jiàn)問(wèn)題列表
生物活性
UNC 0631 是一種有效的組蛋白甲基轉(zhuǎn)移酶 G9a 抑制劑，IC50 值為 4 nM。UNC 0631 有效降低 MDA-MB-231 細(xì)胞中 H3K9me2 的水平，IC50 為 25 nM。靶點(diǎn)
|
G9a 4 nM (IC 50 ) |
體外研究
UNC 0631 (Compound 7) has high cellular potency and excellent separation of functional potency versus cell toxicity in a variety of cell lines. UNC 0631 is highly potent in reducing H3K9me2 levels and has low cell toxicity. UNC 0631 reduces H3K9me2 levels with ICW IC 50 values of 25 nM, 18 nM, 26 nM, 24 nM, 51 nM, 72 nM and 46 nM in MDA-MB-231, MCF7, PC3, 22RV1, HCT116 wt, HCT 116 p53 -/- and IMR90 cell lines, respectively.