777-37-7
777-37-7 結(jié)構(gòu)式
基本信息
2-氯-5-硝基三氟甲基苯
2-氯-5-硝基三氟化甲苯
2-CHLORO-5-NITRO-A,A,A-TRIFLUOROTOLUENE
2-CHLORO-5-NITRO-ALPHA,ALPHA,ALPHA-TRIFLUOROTOLUENE
2-CHLORO-5-NITROBENZOTRIFLUORIDE
2-CHLORO-A,A,A-TRIFLUORO-5-NITROTOLUENE
4-Nitro-2-(trifluoromethyl)chlorobenzene
5-NITRO-2-CHLOROBENZOTRIFLUORIDE
TIMTEC-BB SBB007665
1-chloro-4-nitro-2-(trifluoromethyl)-benzen
2-(Trifluoromethyl)-4-nitrochlorobenzene
2-chloro-1-trifluoromethyl-5-nitro-benzene
2-chloro-5-nitro-α,α,α-trifluorotoluene
2-Chloro-alpha,alpha,alpha-trifluoro-5-nitrotoluene
3-(Trifluoromethyl)-4-chloronitrobenzene
4-Chloro-3-(trifluoromethyl)nitrobenzene
Benzene,1-chloro-4-nitro-2-(trifluoromethyl)-
Toluene, 2-chloro-alpha,alpha,alpha-trifluoro-5-nitro-
α,α,α-trifluoro-2-chloro-5-nitrotoluene
2-Chloro-5-nitrobenzotrifluoride 98%
2-Chloro-5-nitrobenzotrifluoride98%
物理化學(xué)性質(zhì)
NIOSH: IDLH 250 mg/m3
安全數(shù)據(jù)
制備方法
88-16-4
777-37-7
1) 將400g鄰氯三氟甲苯（原料I）加入預(yù)熱模塊2。將濃硫酸（原料II）和濃硝酸（原料III）分別加入預(yù)熱模塊1進(jìn)行混合和預(yù)熱。隨后，將原料I、II和III引入反應(yīng)模塊組中進(jìn)行硝化反應(yīng)。通過調(diào)節(jié)流量泵，控制原料I的流速為15 mL/min，原料II的流速為18 mL/min，原料III的流速為11.5 mL/min。反應(yīng)溫度維持在60℃。鄰氯三氟甲苯與硝酸的摩爾比為1:1.2，濃硝酸與濃硫酸的質(zhì)量比為1:4.0，反應(yīng)停留時間為55秒。冷卻模塊的溫度設(shè)置為25℃。收集冷卻模塊出口的反應(yīng)液，進(jìn)行液-液分離。向酸相中加入270 mL二氯甲烷，將產(chǎn)物與有機相合并。用飽和碳酸氫鈉溶液洗滌至中性，隨后用無水硫酸鈉干燥。減壓蒸發(fā)溶劑后，得到480.36 g 2-氯-5-硝基三氟甲苯，呈黃色油狀物。產(chǎn)率為96.13%，純度為99.29%。
參考文獻(xiàn)：
[1] Patent: CN108191670, 2018, A. Location in patent: Paragraph 0046; 0048-0049; 0052; 0055; 0058; 0061-0067
[2] Asian Journal of Chemistry, 2011, vol. 23, # 5, p. 2284 - 2288
[3] Asian Journal of Chemistry, 2012, vol. 24, # 9, p. 3976 - 3980
[4] Carbohydrate Research, 2018, vol. 457, p. 32 - 40
[5] Patent: US2257093, 1937,