900515-16-4

中文名稱 5-[[5-(4-氟-2-羥基苯基)-2-呋喃基]亞甲基]-2,4-噻唑烷二酮

英文名稱 5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione

CAS 900515-16-4

分子式 C14H8FNO4S

分子量 305.28

MOL 文件 900515-16-4.mol

更新日期 2026/06/01 11:31:38

900515-16-4 結(jié)構(gòu)式

基本信息物理化學性質(zhì) 安全數(shù)據(jù) 常見問題列表圖譜信息 5-[[5-(4-氟-2-羥基苯基)-2-呋喃基]亞甲基]-2,4-噻唑烷二酮價格(試劑級)

基本信息

中文別名

化合物AS-252424
PI3KΓ抑制劑(AS-252424)
5-[[5-(4-氟-2-羥基苯基)-2-呋喃基]亞甲基]-2,4-噻唑烷二酮
5-[[5-(4-氟-2-羥基苯基)-2-呋喃基]亞甲基]-2,4-噻唑烷二酮 2MG

英文別名

CS-182
AS-252424
AS-252424cas
AS-252424
AS 252424
5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
(Z)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)methylene)thiazolidine-2,4-dione
(E)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)Methylene)thiazolidine-2,4-dione
(5Z)-5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
2,4-Thiazolidinedione, 5-[[5-(4-fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-, (5Z)-
AS 252424 5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione

物理化學性質(zhì)

熔點>235oC (dec.)

儲存條件2-8°C

溶解度二甲基亞砜：>20mg/mL

形態(tài)固體

顏色黃色

安全數(shù)據(jù)

危險性符號(GHS) 有害 (GHS07)

GHS07

警示詞警告

危險性描述H302-H315-H319

防范說明P305+P351+P338

WGK Germany3

常見問題列表

生物活性

AS-252424是一種新型，有效的PI3Kγ抑制劑，IC50為30 nM，作用于PI3Kγ比作用于PI3Kα選擇性高30倍，對PI3Kδ/β具有低的抑制活性。

體外研究

AS-252424 is a furan-2-ylmethylene thiazolidinedione as a selective ATP-competitive PI3Kγ inhibitor with IC50 with 33 nM. AS-252424 shows reduced potency on PI3Kα with an IC50 with 935 nM. When screening against 80 different Ser/Thr and Tyr kinases, AS-252424 doesn't show significant inhibit towards any of them at 10 μM except for CK2. AS-252424 inhibits C5a-mediated PKB/Akt phosphorylation in a concentration- dependent manner with submicromolar or low-micromolar IC50 value. AS-252424 inhibits MCP-1-mediated chemotaxis in wild-type primary monocytes in a concentration-dependent manner with an IC50 value of 52 μM, as well as in the monocytic cell line THP-1 with an IC50 value of 53 μM. AS252424 specifically blocks proliferation in the pancreatic cancer cell lines HPAF and Capan1, as assessed by cell counting. A recent research indicates 100 nM of AS-252424 significantly reduces [Ca²⁺]i, I_Ca and Ca²⁺ transients in HL-1 cardiomyocytes.

體內(nèi)研究

Oral administration of AS-252424 at 10 mg/kg results in moderate reduction of neutrophil recruitment (35%), almost matching the result observed in PI3Kγ-deficient mice.

靶點

PI3Kα

935 nM (IC ₅₀ )

PI3Kγ

30 nM (IC ₅₀ )

PI3Kδ

20 μM (IC ₅₀ )

PI3Kβ

20 μM (IC ₅₀ )

圖譜信息

5-[[5-(4-氟-2-羥基苯基)-2-呋喃基]亞甲基]-2,4-噻唑烷二酮(900515-16-4)核磁圖(¹HNMR)

5-[[5-(4-氟-2-羥基苯基)-2-呋喃基]亞甲基]-2,4-噻唑烷二酮價格(試劑級)

報價日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價格
2025/12/22	HY-13532	5-[[5-(4-氟-2-羥基苯基)-2-呋喃基]亞甲基]-2,4-噻唑烷二酮 AS-252424	900515-16-4	1 mg	350元
2025/12/22	HY-13532	5-[[5-(4-氟-2-羥基苯基)-2-呋喃基]亞甲基]-2,4-噻唑烷二酮 AS-252424	900515-16-4	5mg	770元
2025/12/22	HY-13532	5-[[5-(4-氟-2-羥基苯基)-2-呋喃基]亞甲基]-2,4-噻唑烷二酮 AS-252424	900515-16-4	10mM * 1mLin DMSO	847元