Elvitegravir
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- CAS-Nr.
- 697761-98-1
- Englisch Name:
- Elvitegravir
- Synonyma:
- EVG;D06677;CS-789;CS-456;JTK 303;GS 9137;Vitekta;For Mr Wei;Elvitegravi;Elvitegravir
- CBNumber:
- CB02464875
- Summenformel:
- C23H23ClFNO5
- Molgewicht:
- 447.88
- MOL-Datei:
- 697761-98-1.mol
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Elvitegravir Eigenschaften
- Schmelzpunkt:
- 93-96°C
- Siedepunkt:
- 623.6±55.0 °C(Predicted)
- Dichte
- 1.357±0.06 g/cm3(Predicted)
- storage temp.
- Refrigerator
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- pka
- 0.44±0.20(Predicted)
- Aggregatzustand
- Solid
- Farbe
- Off-White to Pale Yellow
- Optische Rotation
- [α]/D -26 to -34°, c =0.5 in methanol
- InChIKey
- JUZYLCPPVHEVSV-LJQANCHMSA-N
- SMILES
- N1([C@H](CO)C(C)C)C2=C(C=C(CC3=CC=CC(Cl)=C3F)C(OC)=C2)C(=O)C(C(O)=O)=C1
- CAS Datenbank
- 697761-98-1
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Aquatic Acute 1
Aquatic Chronic 2 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H412 |
Sch?dlich für Wasserorganismen, mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 3 |
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P273, P501 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Elvitegravir Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
In November 2013, the European Medicines Agency (EMA) approved elvitegravir (also known as GS 9137 and JTK 303) as a single agent to be used as part of an antiviral regimen that includes a ritonavir-boosted protease inhibitor for the treatment of HIV-1 in adults without mutations indicative of elvitegravir resistance. Elvitegravir is the second of three marketed HIV integrase strand transfer inhibitors (INSTIs) including raltegravir and dolutegravir (this volume of ARMC). Elvitegravir was discovered by modification of a literature naphthyridine HIV integrase inhibitor in which the naphthyridine core served as a bioisostere for the diketo acid moiety in an original series. Serendipitously, a 4-quinolone-3-carboxylic acid precursor en route to the desired bioisosteric glyoxylic acid demonstrated modest integrase inhibition (IC
50=1600 nM). Further derivatization led to elvitegravir with enhanced inhibition of integrase strand transfer (IC
50=7.2 nM) and significant antiviral activity (EC
50=0.9 nM). Elvitegravir was prepared in seven synthetic steps from 2,4-difluoro-5-iodobenzoic acid. The corresponding acid chloride was coupled to ethyl 3-(dimethylamino) acrylate and further substituted with S-valinol. Base promoted cyclization afforded the quinolone which was protected as silyl ether. Negishi coupling installed the 2-fluoro-3-chlorobenzyl moiety. Subsequent hydrolysis and methoxylation afforded elvitegravir.
Chemische Eigenschaften
Off-White to Pale Yellow Solid
Verwenden
A novel inhibitor of human immunodeficiency virus type 1 integrase.
Definition
ChEBI: A quinolinemonocarboxylic acid that is 7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid substited at position 1 by a 1-hydroxy-3-methylbutan-2-yl group and at position 6 by a 3-chloro-2-fluorobenzyl group (the S-enantiomer). It is us
d in combination therapy for the treatment of HIV-1 infection.
Elvitegravir Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Elvitegravir Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 262)Lieferanten
697761-98-1()Verwandte Suche:
- Elvitegravir,EVG,GS-9137,JTK-303
- (S)-6-(3-CHLORO-2-FLUOROBENZYL)-1-(1-HYDROXY-3-METHYLBUTAN-2-YL)-7-METHOXY-4-OXO
- 6-[(3-chloro-2-fluorophenyl)Methyl]-1-[(2S)-1-hydroxy-2,3-diMethylbutan-2-yl]-7-Methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
- GS 9137
- JTK 303
- 6-[(3-Chloro-2-fluorophenyl)Methyl]-1,4-dihydro-1-[(1S)-1-(hydroxyMethyl)-2-Methylpropyl]-7-Methoxy-4-oxo-3-quinolinecarboxylic Acid
- D06677
- Elvitegravir (GS-9137)
- Vitekta
- 6-(3-Chloro-2-fluorobenzyl)-1-[1(S)-(hydroxymethyl)-2-methylpropyl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid Elvitegravir (GS-9137, JTK-303)
- (S)-6-(3-CHLORO-2-FLUOROBENZYL)-1-(1-HYDROXY-3-METHYLBUTAN-2-YL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID
- (S)-6-(3-Chloro-2-fluorobenzyl)-1-(1-hydroxy-3-methylBUTAN-2-YL)-7-methoxy-4-oxo-1,4-dihydroqu
- 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
- (S)-6-(3-CHLORO-2-FLUOROBENZYL)-1-(1-HYDROXY-2,3-DIMETHYLBUTAN-2-YL)-7-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID
- Elvitegravir(GS-9137,JTK-303)
- Elvitegravir
- 6-(3-Chloro-2-fluorobenzyl)-1-[1(S)-(hydroxymethyl)-2-methylpropyl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
- (S)-6-(3-CHLORO-2-FLUOROBENZYL)-1-(1-HYDROXY-3-METHYLBUTAN-2-YL)-7-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID
- CS-789
- CS-456
- GS9137;GS-9137;GS 9137
- brand name: Stribild
- GS-9137; GS9137; GS 9137; JTK 303; JTK-303; JTK303; EVG; ELVITEGRAVIR; BRAND NAME: STRIBILD
- 3-Quinolinecarboxylic acid, 6-[(3-chloro-2-fluorophenyl)methyl]-1,4-dihydro-1-[(1S)-1-(hydroxymethyl)-2-methylpropyl]-7-methoxy-4-oxo-
- Elvitegravi
- ELVITEGRAVIR CAS 697761-98-1
- (S)-6-(3-CHLORO-2-FLUOROBENZYL)-1-(1-HYDROXY-3-METHYLBUTAN-2-YL)-7-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID USP/EP/BP
- 6-[(3-chloro-2-fluorophenyl)methyl]-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxoquinoline-3-carboxylic acid
- ElvitegravirQ: What is
Elvitegravir Q: What is the CAS Number of
Elvitegravir Q: What is the storage condition of
Elvitegravir Q: What are the applications of
Elvitegravir
- Elvitegravir (JTK-303)
- For Mr Wei
- Elvitegravir, quinolone HIV integrase inhibitor
- Elvitegravir, 10 mM in DMSO
- EVG
- 697761-98-1
- 595037-20-2
- C23H23ClFNO5
- API
- Inhibitor
- Aromatics
- Heterocycles
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- 697761-98-1
