こはく酸プルカロプリド 化學(xué)特性,用途語,生産方法
効能
消化管運(yùn)動改善薬, セロトニン受容體作動薬
化學(xué)的特性
Butanedioic acid 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide is Off-White to Pale Brown Solid
使用
Prucalopride Succinate is the succinate form of prucalopride. It is a selective 5-HT4 receptor agonist used for the treatment of chronic constipation in adults for whom laxatives are not effective. It is not indicated for use in children and adolescents under 18 years of age.
作用機(jī)序
The succinate form of prucalopride is an orally bioavailable dihydrobenzofurancarboxamide and selective serotonin (5-HT4) receptor agonist with pro-gastrointestinal motility activity. Upon oral administration, procalcitonin specifically targets, binds and stimulates 5-HT4 receptors. This alters the pattern of colonic motility and stimulates large amounts of peristalsis in the colon. This normalises bowel movements and relieves chronic constipation. In addition, by increasing peristalsis in the oesophagus and stomach, prucalopride also relieves symptoms associated with inhalation.
臨床応用
Prucalopride succinate, a first-in-class dihydrobenzofurancarboxamide, is a selective serotonin (5-
HT4) receptor agonist. The drug, marketed under the brand name Resolor®, possesses
enterokinetic activity and was developed by the Belgian-based pharmaceutical firm Movetis.
Prucalopride alters colonic motility patterns via serotonin 5-HT4 receptor stimulation, triggering the
central propulsive force for defecation.
副作用
The most common adverse reactions to Prucalopride Succinate include: headache, nausea, diarrhoea and abdominal pain, loss of appetite, dizziness, vomiting, digestive disturbances (dyspepsia), windiness, abnormal bowel sounds, and tiredness. Other side effects that may come out below are: tremor, rapid heartbeat, rectal bleeding, increased urination (pollenuria), fever, overall general feeling of malaise, flatulence. Severe allergic reactions are rare and manifest as hives or lumps, itching, rash，redness of the skin, facial swelling, and chest tightness. Contact your doctor if any of these serious adverse reactions occur.
こはく酸プルカロプリド 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品