GSK 525762A
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- $32 - $11200
- Product name: GSK 525762A
- CAS: 1260907-17-2
- MF: C22H22ClN5O2
- MW: 423.9
- EINECS:
- MDL Number:MFCD30207861
- Synonyms:I-BET-762;GSK 525762A (I-BET-762);GSK525762 (I-BET-762);4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine-4-acetamide, 6-(4-chlorophenyl)-N-ethyl-8-methoxy-1-methyl-, (4S)-;(4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide GSK 525762A I-BET-762;GSK 525762A (4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide;IBET762(GSK525762A);GSK 525762A
86 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- ApexBio Technology
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth
- BroadPharm
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 200mg
- 250mg
- 1g
- 2.00g
- 3500mg
- 5g
- 5.00g
- 5000mg
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 25
- 10.00g
- 10mM(in1mLDMSO)
- 10000mg
- 10mM*1mLinDMSO
- 5 mg
- Manufactureraablocks
- Product numberAA000RJ5
- Product description(4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide 98+%
- Packaging1mg
- Price$32
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000RJ5
- Product description(4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide 98+%
- Packaging2mg
- Price$42
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000RJ5
- Product description(4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide 98+%
- Packaging5mg
- Price$74
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000RJ5
- Product description(4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide 98+%
- Packaging10mg
- Price$108
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000RJ5
- Product description(4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide 98
- Packaging25mg
- Price$194
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000RJ5
- Product description(4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide 98
- Packaging100mg
- Price$448
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000RJ5
- Product description(4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide 98
- Packaging50mg
- Price$307
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15773
- Product descriptionGSK525762 98%
- Packaging100MG
- Price$640
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15773
- Product descriptionGSK525762 98%
- Packaging100MG
- Price$640
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15773
- Product descriptionGSK525762 98%
- Packaging25MG
- Price$260
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15773
- Product descriptionGSK525762 98%
- Packaging25MG
- Price$260
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-3033-M050
- Product descriptionI-BET762 ≥95%
- Packaging50mg
- Price$486
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-3033-M100
- Product descriptionI-BET762 ≥95%
- Packaging100mg
- Price$778
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-3033-M001
- Product descriptionI-BET762 ≥95%
- Packaging1mg
- Price$86
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-3033-M005
- Product descriptionI-BET762 ≥95%
- Packaging5mg
- Price$130
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-3033-M010
- Product descriptionI-BET762 ≥95%
- Packaging10mg
- Price$173
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA000RJ5 | (4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide 98+% | 1mg | $32 | 2026-05-25 | Buy |
| aablocks | AA000RJ5 | (4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide 98+% | 2mg | $42 | 2026-05-25 | Buy |
| aablocks | AA000RJ5 | (4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide 98+% | 5mg | $74 | 2026-05-25 | Buy |
| aablocks | AA000RJ5 | (4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide 98+% | 10mg | $108 | 2026-05-25 | Buy |
| aablocks | AA000RJ5 | (4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide 98 | 25mg | $194 | 2026-05-25 | Buy |
| aablocks | AA000RJ5 | (4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide 98 | 100mg | $448 | 2026-05-25 | Buy |
| aablocks | AA000RJ5 | (4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide 98 | 50mg | $307 | 2026-05-25 | Buy |
| ACHEMBLOCK | M15773 | GSK525762 98% | 100MG | $640 | 2026-05-25 | Buy |
| ACHEMBLOCK | M15773 | GSK525762 98% | 100MG | $640 | 2026-05-27 | Buy |
| ACHEMBLOCK | M15773 | GSK525762 98% | 25MG | $260 | 2026-05-25 | Buy |
| ACHEMBLOCK | M15773 | GSK525762 98% | 25MG | $260 | 2026-05-27 | Buy |
| Adipogen Life Sciences | SYN-3033-M050 | I-BET762 ≥95% | 50mg | $486 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-3033-M100 | I-BET762 ≥95% | 100mg | $778 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-3033-M001 | I-BET762 ≥95% | 1mg | $86 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-3033-M005 | I-BET762 ≥95% | 5mg | $130 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-3033-M010 | I-BET762 ≥95% | 10mg | $173 | 2026-05-06 | Buy |
Properties
Melting point :>132°C (dec.)
Density :1.35
storage temp. :2-8°C
solubility :Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml)
form :powder
pka :15.71±0.46(Predicted)
color :white to beige
optical activity :[α]/D +80 to +90°, c = 0.3 in methanol
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI :1S/C22H22ClN5O2/c1-4-24-20(29)12-18-22-27-26-13(2)28(22)19-10-9-16(30-3)11-17(19)21(25-18)14-5-7-15(23)8-6-14/h5-11,18H,4,12H2,1-3H3,(H,24,29)/t18-/m0/s1
InChIKey :AAAQFGUYHFJNHI-SFHVURJKSA-N
SMILES :Clc1ccc(cc1)C2=N[C@H](c3[n](c(nn3)C)c4c2cc(cc4)OC)CC(=O)NCC
Density :1.35
storage temp. :2-8°C
solubility :Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml)
form :powder
pka :15.71±0.46(Predicted)
color :white to beige
optical activity :[α]/D +80 to +90°, c = 0.3 in methanol
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI :1S/C22H22ClN5O2/c1-4-24-20(29)12-18-22-27-26-13(2)28(22)19-10-9-16(30-3)11-17(19)21(25-18)14-5-7-15(23)8-6-14/h5-11,18H,4,12H2,1-3H3,(H,24,29)/t18-/m0/s1
InChIKey :AAAQFGUYHFJNHI-SFHVURJKSA-N
SMILES :Clc1ccc(cc1)C2=N[C@H](c3[n](c(nn3)C)c4c2cc(cc4)OC)CC(=O)NCC
Safety Information
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Description
The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, affect inflammatory gene expression by controlling the assembly of histone acetylation-dependent chromatin complexes. I-BET762 is a synthetic compound which interacts with BET proteins with high-affinity (Kd = 32.5-42.5 nM). It blocks binding of BET proteins with acetylated histones, disrupting the formation of chromatin complexes involved in the expression of specific inflammatory genes in activated macrophages. Through these actions, I-BET762 provides protection against bacteria-induced sepsis and lipopolysaccharide-triggered endotoxic shock.More related product prices
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