Pifithrin-μ
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- $30 - $1802
- Product name: Pifithrin-μ
- CAS: 64984-31-2
- MF: C8H7NO2S
- MW: 181.21
- EINECS:
- MDL Number:MFCD00181531
- Synonyms:PHENYLETHYNSULFONIC ACID AMIDE;Pifithrin--;Phenyl-ethynesulfonic Acid Amide;Pifithrin-u;2-Phenylethynesulfonamide, PFTμ;EthynesulfonaMide, 2-phenyl-;NSC 303580;Pftmu
72 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 10.00mg
- 25.00mg
- 50.00mg
- 10mM*1mLinDMSO
- 250mg
- 1000mg
- 10
- 50
- 5g
- 5mg
- 10mM(in1mLDMSO)
- 10mg
- 25mg
- 10mM(1mLinDMSO)
- 50mg
- 100mg
- 500MG
- 1g
- Manufactureraablocks
- Product numberAA00EBJ6
- Product description2-phenylacetylenesulfonamide 98
- Packaging25mg
- Price$104
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00EBJ6
- Product description2-phenylacetylenesulfonamide 98
- Packaging50mg
- Price$143
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00EBJ6
- Product description2-phenylacetylenesulfonamide 98
- Packaging100mg
- Price$204
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00EBJ6
- Product description2-phenylacetylenesulfonamide 98%
- Packaging10mg
- Price$46
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00EBJ6
- Product description2-phenylacetylenesulfonamide 98%
- Packaging5mg
- Price$30
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228723
- Product descriptionPIFITHRIN-MU 97.00%
- Packaging100MG
- Price$275
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228723
- Product descriptionPIFITHRIN-MU 97.00%
- Packaging500MG
- Price$825
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberX5920
- Product description2-phenylacetylenesulfonamide
- Packaging1g
- Price$619
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0014835
- Product descriptionPHENYLETHYNSULFONIC ACID AMIDE 95.00%
- Packaging10MG
- Price$721.88
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0014835
- Product descriptionPHENYLETHYNSULFONIC ACID AMIDE 95.00%
- Packaging100MG
- Price$1732.5
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4482
- Product descriptionPifithrin-μ
- Packaging50mg
- Price$190
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4482
- Product descriptionPifithrin-μ
- Packaging50mg
- Price$190
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4482
- Product descriptionPifithrin-μ
- Packaging10mg
- Price$55
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4482
- Product descriptionPifithrin-μ
- Packaging10mM(in1mLDMSO)
- Price$60
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberSLK-S2930
- Product descriptionPifithrin-μ 99.93%
- Packaging10mg
- Price$140
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-S2930
- Product descriptionPifithrin-μ 99.93%
- Packaging10mM(1mLinDMSO)
- Price$188
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00EBJ6 | 2-phenylacetylenesulfonamide 98 | 25mg | $104 | 2026-05-28 | Buy |
| aablocks | AA00EBJ6 | 2-phenylacetylenesulfonamide 98 | 50mg | $143 | 2026-05-28 | Buy |
| aablocks | AA00EBJ6 | 2-phenylacetylenesulfonamide 98 | 100mg | $204 | 2026-05-28 | Buy |
| aablocks | AA00EBJ6 | 2-phenylacetylenesulfonamide 98% | 10mg | $46 | 2026-05-28 | Buy |
| aablocks | AA00EBJ6 | 2-phenylacetylenesulfonamide 98% | 5mg | $30 | 2026-05-28 | Buy |
| ACHEMBLOCK | Y228723 | PIFITHRIN-MU 97.00% | 100MG | $275 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y228723 | PIFITHRIN-MU 97.00% | 500MG | $825 | 2026-05-27 | Buy |
| AK Scientific | X5920 | 2-phenylacetylenesulfonamide | 1g | $619 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0014835 | PHENYLETHYNSULFONIC ACID AMIDE 95.00% | 10MG | $721.88 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0014835 | PHENYLETHYNSULFONIC ACID AMIDE 95.00% | 100MG | $1732.5 | 2021-12-16 | Buy |
| ApexBio Technology | A4482 | Pifithrin-μ | 50mg | $190 | 2021-12-16 | Buy |
| ApexBio Technology | A4482 | Pifithrin-μ | 50mg | $190 | 2026-05-06 | Buy |
| ApexBio Technology | A4482 | Pifithrin-μ | 10mg | $55 | 2026-05-06 | Buy |
| ApexBio Technology | A4482 | Pifithrin-μ | 10mM(in1mLDMSO) | $60 | 2026-05-06 | Buy |
| Arctom | SLK-S2930 | Pifithrin-μ 99.93% | 10mg | $140 | 2026-05-26 | Buy |
| Arctom | SLK-S2930 | Pifithrin-μ 99.93% | 10mM(1mLinDMSO) | $188 | 2026-05-26 | Buy |
Properties
Melting point :135.0 to 139.0 °C
Boiling point :351.7±25.0 °C(Predicted)
Density :1.39±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble >10mg/mL, clear
pka :7.96±0.60(Predicted)
form :solid
color :White or off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI :InChI=1S/C8H7NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-5H,(H2,9,10,11)
InChIKey :ZZUZYEMRHCMVTB-UHFFFAOYSA-N
SMILES :C(S(N)(=O)=O)#CC1=CC=CC=C1
Boiling point :351.7±25.0 °C(Predicted)
Density :1.39±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble >10mg/mL, clear
pka :7.96±0.60(Predicted)
form :solid
color :White or off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI :InChI=1S/C8H7NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-5H,(H2,9,10,11)
InChIKey :ZZUZYEMRHCMVTB-UHFFFAOYSA-N
SMILES :C(S(N)(=O)=O)#CC1=CC=CC=C1
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
In addition to its transactivational functions, p53 mediates apoptosis by binding with the anti-apoptotic proteins Bcl-xL and Bcl-2 at the mitochondrial surface. Pifithrin-μ (PFT-μ) is an inhibitor of p53-mediated apoptosis, preventing p53 binding to Bcl-xL and Bcl-2 at the mitochondria without affecting p53 transactivational activities In vitro, PFT-μ binds both p53 (Kd = 0.82 mM) and Bcl-xL (Kd = 0.80 mM). PFT-μ reduces p53-mediated apoptosis induced by γ-radiation in mouse thymocytes in vitro and protects mice from doses of radiation that cause lethal hematopoietic syndrome. At 25 μM, PFT-μ reduces apoptosis triggered by nutlin-3, which inhibits MDM2/p53 binding and potentiates p53-mediated growth arrest and apoptosis. PFT-μ also interacts selectively with heat shock protein 70 (HSP70), leading to disruption of the association between HSP70 and many of its co-chaperones and substrate proteins.More related product prices
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