S3I-201
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- $12 - $5346
- Product name: S3I-201
- CAS: 501919-59-1
- MF: C16H15NO7S
- MW: 365.36
- EINECS:
- MDL Number:MFCD09907564
- Synonyms:S2I-201;2-Hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]benzoic acid NSC 74859(S3I-201);2-Hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid;Stat3 Inhibitor I, S3I-201;OTAVA-BB 7070707021;S31-201 (NSC 74859);NSC 74859, >=98%;OTAVA-BB 7070707021S31-201 (NSC 74859)，S3I-201
74 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 250mg
- 10mM*1mLinDMSO
- 25mg
- 50
- 10g
- 50.00g
- 10
- 100.00g
- 250.00g
- EvaluationSample
- 1mg
- 5mg
- 10mg
- 50mg
- 200mg
- 100MG
- 1G
- 5g
- 10mM(in1mLDMSO)
- Manufactureraablocks
- Product numberAA00DB4A
- Product description2-Hydroxy-4-(2-(tosyloxy)acetamido)benzoic acid 99%
- Packaging1mg
- Price$12
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DB4A
- Product description2-Hydroxy-4-(2-(tosyloxy)acetamido)benzoic acid 99%
- Packaging5mg
- Price$22
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DB4A
- Product description2-Hydroxy-4-(2-(tosyloxy)acetamido)benzoic acid 99%
- Packaging10mg
- Price$30
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00DB4A
- Product description2-Hydroxy-4-(2-(tosyloxy)acetamido)benzoic acid 99%
- Packaging50mg
- Price$76
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product number10373
- Product descriptionS3I-201 98%
- Packaging100MG
- Price$140
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10373
- Product descriptionS3I-201 98%
- Packaging1G
- Price$700
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberX7562
- Product description2-Hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoicacid
- Packaging5g
- Price$4861
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8338
- Product descriptionNSC 74859
- Packaging200mg
- Price$581
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8338
- Product descriptionNSC 74859
- Packaging50mg
- Price$194
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8338
- Product descriptionNSC 74859
- Packaging10mg
- Price$77
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8338
- Product descriptionNSC 74859
- Packaging10mM(in1mLDMSO)
- Price$83
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8338
- Product descriptionNSC74859
- Packaging10mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8338
- Product descriptionNSC 74859
- PackagingEvaluationSample
- Price$30
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberCFN60350
- Product descriptionS3I-201 ≥98%
- Packaging10mg
- Price$168
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2313
- Product descriptionS3I201-NSC74859 99%
- Packaging10mg
- Price$99
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2313
- Product descriptionS3I 201
- Packaging10mg
- Price$99
- Updated2026-05-19
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00DB4A | 2-Hydroxy-4-(2-(tosyloxy)acetamido)benzoic acid 99% | 1mg | $12 | 2026-05-28 | Buy |
| aablocks | AA00DB4A | 2-Hydroxy-4-(2-(tosyloxy)acetamido)benzoic acid 99% | 5mg | $22 | 2026-05-28 | Buy |
| aablocks | AA00DB4A | 2-Hydroxy-4-(2-(tosyloxy)acetamido)benzoic acid 99% | 10mg | $30 | 2026-05-28 | Buy |
| aablocks | AA00DB4A | 2-Hydroxy-4-(2-(tosyloxy)acetamido)benzoic acid 99% | 50mg | $76 | 2026-05-28 | Buy |
| ACHEMBLOCK | 10373 | S3I-201 98% | 100MG | $140 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10373 | S3I-201 98% | 1G | $700 | 2026-05-27 | Buy |
| AK Scientific | X7562 | 2-Hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoicacid | 5g | $4861 | 2021-12-16 | Buy |
| ApexBio Technology | A8338 | NSC 74859 | 200mg | $581 | 2026-05-06 | Buy |
| ApexBio Technology | A8338 | NSC 74859 | 50mg | $194 | 2026-05-06 | Buy |
| ApexBio Technology | A8338 | NSC 74859 | 10mg | $77 | 2026-05-06 | Buy |
| ApexBio Technology | A8338 | NSC 74859 | 10mM(in1mLDMSO) | $83 | 2026-05-06 | Buy |
| ApexBio Technology | A8338 | NSC74859 | 10mg | $70 | 2021-12-16 | Buy |
| ApexBio Technology | A8338 | NSC 74859 | EvaluationSample | $30 | 2026-05-06 | Buy |
| Arctom | CFN60350 | S3I-201 ≥98% | 10mg | $168 | 2021-12-16 | Buy |
| Axon Medchem | Axon2313 | S3I201-NSC74859 99% | 10mg | $99 | 2021-12-16 | Buy |
| Axon Medchem | Axon2313 | S3I 201 | 10mg | $99 | 2026-05-19 | Buy |
Properties
Melting point :>185oC (dec.)
Boiling point :654.7±55.0 °C(Predicted)
Density :1.507
storage temp. :-20°C
solubility :DMSO: >10mg/mL
pka :2.98±0.10(Predicted)
form :powder
color :white to beige
InChI :InChI=1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)
InChIKey :HWNUSGNZBAISFM-UHFFFAOYSA-N
SMILES :C(O)(=O)C1=CC=C(NC(COS(C2=CC=C(C)C=C2)(=O)=O)=O)C=C1O
Boiling point :654.7±55.0 °C(Predicted)
Density :1.507
storage temp. :-20°C
solubility :DMSO: >10mg/mL
pka :2.98±0.10(Predicted)
form :powder
color :white to beige
InChI :InChI=1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)
InChIKey :HWNUSGNZBAISFM-UHFFFAOYSA-N
SMILES :C(O)(=O)C1=CC=C(NC(COS(C2=CC=C(C)C=C2)(=O)=O)=O)C=C1O
Safety Information
| Symbol(GHS): |
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
Signal transducers and activators of transcription (STATs) are a family of latent cytoplasmic transcription factors that convey signals from the cell membrane to the nucleus. In various human tumors, STAT3 is constitutively activated by aberrant upstream tyrosine kinase activities. STAT signaling is also suspected to play a role in vascular disease since it can be activated through angiotensin II type 1 receptors or the inflammatory mediator interleukin (IL)-6. S3I-201 is an inhibitor of STAT3 transcription factor activation, dimerization, and gene transcription. It can suppress IL-6-induced phosphorylation of STAT3 in T cells with an IC50 value of 38 μM. Inhibiting STAT3 activation with 10 μM S3I-201 was demonstrated to be protective against angiotensin II-induced oxidative stress, endothelial dysfunction, and hypertension in two different models of vascular disease. At 10 μM, S3I-201 has also been used as a means to regress cardiac hypertrophy by inhibiting collagen biosynthesis and decreasing atrial natriuretic factor and β-myosin heavy chain in an in vitro model.More related product prices
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