QUINOMYCIN A
|
- $80 - $5958
- Product name: QUINOMYCIN A
- CAS: 512-64-1
- MF: C51H64N12O12S2
- MW: 1101.26
- EINECS:
- MDL Number:MFCD00156105
- Synonyms:echinomycina ;nsc526417 ;N-[(1R,4S,8R,11S,14R,17S,21R,24S)-3,11,13,16,24,26-hexamethyl-27-methylsulfanyl-2,5,9,12,15,18,22,25-octaoxo-4,17-di(propan-2-yl)-8-(quinoxaline-2-carbonylamino)-6,19-dioxa-28-thia-3,10,13,16,23,26-hexazabicyclo[12.12.3]nonacosan-21-yl]quinoxaline-2-carbo;N-(2-Quinoxalinylcarbonyl)cyclo(D-Ser*-Ala-N-methyl-L-Cys(1)-N-methyl-L-Val-N-(quinoxaline-2-ylcarbonyl)-D-Ser*-Ala-N-methyl-3-methylthio-L-Ala(1)-N-methyl-L-Val-);SK-302B;Echinomycin >97%;N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl L-valine (81)-lactone cyclic (37)-thioester;Echinomycin (NSC-13502)
33 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- AvaChem
- Cayman Chemical
- ChemScene
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 1
- 1mg
- 2.5mg
- 5mg
- 10mg
- 25mg
- Manufactureraablocks
- Product numberAA00D7U8
- Product descriptionEchinomycin ≥95%
- Packaging1mg
- Price$107
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00D7U8
- Product descriptionEchinomycin ≥95%
- Packaging5mg
- Price$396
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberAD261959
- Product descriptionEchinomycin 97%
- Packaging1MG
- Price$335
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberAD261959
- Product descriptionEchinomycin 97%
- Packaging5MG
- Price$1175
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberBVT-0267-M005
- Product descriptionEchinomycin ≥98%(HPLC)
- Packaging5mg
- Price$320
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberBVT-0267-M005
- Product descriptionEchinomycin ≥98%(HPLC)
- Packaging5mg
- Price$300
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberBVT-0267-M001
- Product descriptionEchinomycin ≥98%(HPLC)
- Packaging1mg
- Price$80
- Updated2026-05-06
- Buy
- ManufacturerAK Scientific
- Product number2677AH
- Product descriptionQuinomycinA
- Packaging5mg
- Price$473
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0010197
- Product descriptionQUINOMYCIN A 95.00%
- Packaging1MG
- Price$1365
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberBA1018
- Product descriptionEchinomycin
- Packaging1mg
- Price$259
- Updated2026-05-06
- Buy
- ManufacturerAvaChem
- Product number6302
- Product descriptionEchinomycin 98%
- Packaging1mg
- Price$90
- Updated2026-05-22
- Buy
- ManufacturerAvaChem
- Product number6302
- Product descriptionEchinomycin 98%
- Packaging5mg
- Price$380
- Updated2026-05-22
- Buy
- ManufacturerCayman Chemical
- Product number11049
- Product descriptionEchinomycin ≥98%
- Packaging5mg
- Price$360
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number11049
- Product descriptionEchinomycin ≥98%
- Packaging1mg
- Price$97
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number11049
- Product descriptionEchinomycin ≥95%
- Packaging1mg
- Price$107
- Updated2026-04-30
- Buy
- ManufacturerCayman Chemical
- Product number11049
- Product descriptionEchinomycin ≥95%
- Packaging5mg
- Price$396
- Updated2026-04-30
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00D7U8 | Echinomycin ≥95% | 1mg | $107 | 2026-05-28 | Buy |
| aablocks | AA00D7U8 | Echinomycin ≥95% | 5mg | $396 | 2026-05-28 | Buy |
| ACHEMBLOCK | AD261959 | Echinomycin 97% | 1MG | $335 | 2026-05-27 | Buy |
| ACHEMBLOCK | AD261959 | Echinomycin 97% | 5MG | $1175 | 2026-05-27 | Buy |
| Adipogen Life Sciences | BVT-0267-M005 | Echinomycin ≥98%(HPLC) | 5mg | $320 | 2026-05-06 | Buy |
| Adipogen Life Sciences | BVT-0267-M005 | Echinomycin ≥98%(HPLC) | 5mg | $300 | 2021-12-16 | Buy |
| Adipogen Life Sciences | BVT-0267-M001 | Echinomycin ≥98%(HPLC) | 1mg | $80 | 2026-05-06 | Buy |
| AK Scientific | 2677AH | QuinomycinA | 5mg | $473 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0010197 | QUINOMYCIN A 95.00% | 1MG | $1365 | 2021-12-16 | Buy |
| ApexBio Technology | BA1018 | Echinomycin | 1mg | $259 | 2026-05-06 | Buy |
| AvaChem | 6302 | Echinomycin 98% | 1mg | $90 | 2026-05-22 | Buy |
| AvaChem | 6302 | Echinomycin 98% | 5mg | $380 | 2026-05-22 | Buy |
| Cayman Chemical | 11049 | Echinomycin ≥98% | 5mg | $360 | 2024-03-01 | Buy |
| Cayman Chemical | 11049 | Echinomycin ≥98% | 1mg | $97 | 2024-03-01 | Buy |
| Cayman Chemical | 11049 | Echinomycin ≥95% | 1mg | $107 | 2026-04-30 | Buy |
| Cayman Chemical | 11049 | Echinomycin ≥95% | 5mg | $396 | 2026-04-30 | Buy |
Properties
Melting point :217-218℃
alpha :D20 -310° (c = 0.86 in chloroform)
Boiling point :1427.2±65.0 °C(Predicted)
Density :1.0964 (rough estimate)
refractive index :1.6700 (estimate)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 5 mg/ml)
pka :9.38±0.70(Predicted)
form :White solid
color :white to beige
Merck :13,3531
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months
InChIKey :AUJXLBOHYWTPFV-UHFFFAOYSA-N
SMILES :S1C(C2N(C(=O)C(NC(=O)C(COC(=O)C(N(C(=O)C(N(C(=O)C(NC(=O)C(COC(=O)C(N(C2=O)C)C(C)C)NC(=O)c5nc6c(nc5)cccc6)C)C)C1)C)C(C)C)NC(=O)c3nc4c(nc3)cccc4)C)C)SC
alpha :D20 -310° (c = 0.86 in chloroform)
Boiling point :1427.2±65.0 °C(Predicted)
Density :1.0964 (rough estimate)
refractive index :1.6700 (estimate)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 5 mg/ml)
pka :9.38±0.70(Predicted)
form :White solid
color :white to beige
Merck :13,3531
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months
InChIKey :AUJXLBOHYWTPFV-UHFFFAOYSA-N
SMILES :S1C(C2N(C(=O)C(NC(=O)C(COC(=O)C(N(C(=O)C(N(C(=O)C(NC(=O)C(COC(=O)C(N(C2=O)C)C(C)C)NC(=O)c5nc6c(nc5)cccc6)C)C)C1)C)C(C)C)NC(=O)c3nc4c(nc3)cccc4)C)C)SC
Safety Information
| Symbol(GHS): |
 
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Danger | ||||||||||||||
| Hazard statements: |
|
||||||||||||||
| Precautionary statements: |
|
Description
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that controls genes involved in glycolysis, angiogenesis, migration, and invasion. Echinomycin is a cell-permeable inhibitor of HIF-1-mediated gene transcription. It acts by intercalating into DNA in a sequence-specific manner, blocking the binding of either HIF-1α or HIF-1β to the hypoxia-responsive element. Echinomycin reversibly inhibits hypoxia-induced HIF-1 transcription activity in U215 cells with an EC50 value of 1.2 nM. It inhibits hypoxia-induced expression of vascular endothelial growth factor, blocking angiogenesis and altering excitatory synaptic transmission in hippocampal neurons. Echinomycin also impairs expression of survivin, enhancing the sensitivity of multiple myeloma cells to melphalan.More related product prices
CHAETOMIN 112901-68-5 Chrysin Azithromycin Imatinib mesylate Geldanamycin Sunitinib Malate 331830-20-7 2-QUINOXALINECARBALDEHYDERelated product price
-
CHAETOMIN
$148.5-2357.9 -
112901-68-5
$6-2159 -
Chrysin
$6-12639
Suppliers and manufacturers
BOC Sciences
Shaanxi Dideu Medichem Co. Ltd
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Zhejiang Huida Biotech Co., LTD
Nextpeptide Inc
Wuhan Topule Biopharmaceutical Co., Ltd
Shanghai Acmec Biochemical Technology Co., Ltd.
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
Aladdin Scientific
