血管緊張素
| 中文名稱 | 血管緊張素 |
|---|---|
| 中文同義詞 | 血管緊張素;醋酸血管緊張素 II ANGIOTENSINII ACETATE;[VAL5]-血管緊張素 II 乙酸鹽 水合物;ANGIOTENSIN受體激動劑(ANGIOTENSIN II 5-VALINE);血管緊張素 Ⅱ 5-纈氨酸, >99%;[VAL5]-血管緊張素 II;血管緊張素 Ⅱ 5-纈氨酸;血管緊張素[VAL5]ANGIOTENSIN II, HUMAN |
| 英文名稱 | Angiotensin acetate |
| 英文同義詞 | [VAL5]-ANGIOTENSIN II;[VAL5] ANGIOTENSIN II HUMAN;ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE;DRVYVHPF;L-ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE;H-ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE-OH;[val5]-angiotensin ii acetate hydrate;Angiotensin acetate |
| CAS號 | 58-49-1 |
| 分子式 | C49H69N13O12 |
| 分子量 | 1032.15 |
| EINECS號 | |
| 相關(guān)類別 | 多肽中間體;醫(yī)藥原料;多肽;醫(yī)藥原料藥;多肽-客戶肽;細胞生物學試劑;對照品-中藥對照品;藥物多肽;肽類 |
| Mol文件 | 58-49-1.mol |
| 結(jié)構(gòu)式 |  |
血管緊張素 性質(zhì)
| 儲存條件 | -20°C |
|---|---|
| 形態(tài) | 粉末 |
| 密度 | 1.45±0.1 g/cm3(Predicted) |
| 酸度系數(shù)(pKa) | 3.56±0.10(Predicted) |
| 顏色 | 白色至米白色 |
| 水溶解性 | Water : ≥ 257.5 mg/mL (249.48 mM) |
| 序列 | H-Asp-Arg-Val-Tyr-Val-His-Pro-Phe-OH |
| InChIKey | JVCJXRGXGITABA-IAQGTVMASA-N |
| CAS 數(shù)據(jù)庫 | 58-49-1 |
Angiotensin receptor.
By day 12, systolic blood pressure (SBP) increases significantly in Angiotensin II 5-valine infused rats (197±7 mm Hg). As shown, the development of hypertension in ANG II infused rats is prevented by losartan treatment. Blood and kidney samples are harvested, subjected to HPLC to separate Angiotensin II 5-valine (exogenous) from Ile5-ANG II (endogenous) and the fractions are measured by radioimmunoassay. In the Angiotensin II 5-valine infused rats treated with losartan, total plasma ANG II levels are elevated to a greater extent than in rats not treated with losartan (289±20 v 119±14 fmol/mL). However, losartan markedly decrease by 88% the enhancement of intrarenal Val5-ANG II content that occurred in the rats infused with Val5-ANG II alone.
純度(HPLC) ≥98.0%
醋酸根含量5.0%～12.0%
水分含量≤8.0%
肽含量≥80.0%
安全信息
| WGK Germany | 3 |
|---|