2,3-吡啶二甲酸
| 中文名稱 | 2,3-吡啶二甲酸 |
|---|---|
| 中文同義詞 | 2,3-吡啶二羧酸(吡啶-2,3-二羧酸、喹啉酸、吡啶-2,3-二酸、吡啶羧酸、吡啉酸、2,3-二羧酸基吡啶);喹啉酸 25G;吡啶-2,3-二酸;吡啶羧酸;吡啉酸;吡啶-2,3-二羧酸;喹啉酸;吡啶2,3-二羧酸 (喹啉酸) |
| 英文名稱 | Quinolinic acid |
| 英文同義詞 | QuinolinicAcid>99%;Pyridin-2,3-dicarbonsaeure;2,3-PYRIDINEDICARBOXYLIC ACID (QUINOLINIC ACID);2,3-pyridine dicarbo;AKOS BBS-00003814;AKOS AUF2085;Quinolinic Acid 99%;2,3-Pyridinedicarboxylic acid, 99% 100GR |
| CAS號 | 89-00-9 |
| 分子式 | C7H5NO4 |
| 分子量 | 167.12 |
| EINECS號 | 201-874-8 |
| 相關(guān)類別 | 通用試劑;原料;有機(jī)化工;醫(yī)藥原料;中間體;吡啶類;醫(yī)藥中間體;除草劑中間體;咪唑啉酮類除草劑;農(nóng)藥中間體;吡啶;雜環(huán)砌塊;化工中間體;有機(jī)化工原料;有機(jī)原料;其他原料;化工原料-塑料類;化工中間體工業(yè)原料;Medical Intermediates;Pyridine series;Pyridine;pyridine derivative;Carboxylic Acids;Pyridines;Heterocyclic Compounds;Heterocycles;Inhibitors;Carboxylic Acids;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Pesticides intermediate;Pyrimidines;原料藥;有機(jī)化工原料;化妝品原料;化工原料;雜質(zhì)對照品;對照品 |
| Mol文件 | 89-00-9.mol |
| 結(jié)構(gòu)式 |  |
2,3-吡啶二甲酸 性質(zhì)
| 熔點(diǎn) | 188-190 °C (dec.) (lit.) |
|---|---|
| 沸點(diǎn) | 295.67°C (rough estimate) |
| 密度 | 1.5216 (rough estimate) |
| 折射率 | 1.6280 (estimate) |
| 儲存條件 | Keep in dark place,Sealed in dry,Room Temperature |
| 溶解度 | 10g/l |
| 形態(tài) | 結(jié)晶粉末 |
| 酸度系數(shù)(pKa) | 2.43(at 25℃) |
| 顏色 | 白色至淺黃米色 |
| 氣味 (Odor) | 無味 |
| 水溶解性 | 0.55 g/100 mL |
| Merck | 14,8073 |
| BRN | 137110 |
| InChI | 1S/C7H5NO4/c9-6(10)4-2-1-3-8-5(4)7(11)12/h1-3H,(H,9,10)(H,11,12) |
| InChIKey | GJAWHXHKYYXBSV-UHFFFAOYSA-N |
| SMILES | OC(=O)c1cccnc1C(O)=O |
| CAS 數(shù)據(jù)庫 | 89-00-9(CAS DataBase Reference) |
| EPA化學(xué)物質(zhì)信息 | 2,3-Pyridinedicarboxylic acid (89-00-9) |
2,3-吡啶二甲酸為無色柱狀結(jié)晶狀，微溶于水，不溶于苯和醚。其可用做醫(yī)藥中間體，農(nóng)藥中間體，有機(jī)合成試劑。
用途
吡啶-2，3-二羧酸是除草劑咪唑煙酸的中間體。用途
抑制葡萄糖的合成用途
喹啉酸是一種具有吡啶骨架的二羧酸，是合成煙酸、菸酰胺、尼可剎米等的中間體，也是銅離子測定試劑。生產(chǎn)方法
其制備方法是以丙烯醛與草酰乙酸二乙酯、氯化銨為原料，在乙醇中催化劑存在下，反應(yīng)加熱回流，冷卻得吡啶-2，3二羧酸酯再水解得產(chǎn)品。生產(chǎn)方法
用喹啉以硝酸氧化制得。安全信息
| 危險品標(biāo)志 | Xi |
|---|---|
| 危險類別碼 | 36/37/38-33 |
| 安全說明 | 26-36/37-24/25-37 |
| WGK Germany | 3 |
| RTECS號 | US7967250 |
| TSCA | TSCA listed |
| 危險等級 | IRRITANT |
| 海關(guān)編碼 | 29333999 |
| 存儲類別 | 11 - 可燃固體 |
| 危險性類別 | 眼部刺激 類別2 特異性靶器官毒性-一次接觸，類別3 |
| 毒害物質(zhì)數(shù)據(jù) | 89-00-9(Hazardous Substances Data) |
| 毒性 | Focal injection of quinolinic acid into specific areas of the brain produces neuronal damage although sparing axons of passage. Similarities between the biochemical and morphological profiles of these lesions and human neuropathy seen in neurodegenerative diseases have led to the proposal that endogenous excitotoxins may play a role in such neurodegenerative disease states. Quinolinic acid is an intermediate in the kynurenine pathway of tryptophan metabolism and has been detected in the brains of several mammals including man. The neuroexcitatory action is thought to be mediated via interaction with the N-methyl-D-aspartate (NMDA) receptor of the glutamate family. No mechanism for quinolinic acid removal, nor for synaptic inactivation, has been found, and consequently accumulation of concentrations capa_x0002_ble of inducing neuronal degeneration and death may occur. |
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