GNE-495 NEW
| Price | $35 | $85 | $148 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-07-17 |
Product Details
| Product Name: GNE-495 | CAS No.: 1449277-10-4 |
| Purity: 99.57% | Supply Ability: 10g |
| Release date: 2026/07/17 |
Product Introduction
Bioactivity
| Name | GNE-495 |
| Description | GNE-495 is a potent and specific inhibitor of MAP4K4 with an IC50 of 3.7 nM. |
| In vitro | GNE-495 has efficacy in retinal angiogenesis. GNE-495 shows the best balance of MAP4K4 inhibition, permeability, microsomal stability, and cellular potency. |
| In vivo | GNE-495 is administered at high doses (25 and 50 mg/kg) intraperitoneally to neonatal mice. This compound demonstrates superior potency and favorable pharmacokinetic (PK) profiles across all tested species, characterized by low clearance rates, moderate terminal half-lives, and acceptable levels of oral bioavailability (F=37-47%). |
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 2 mg/mL (4.93 mM), Sonication is recommended. |
| Keywords | MAPK Kinase Kinase Kinase | MAP4K4 | MAP4K | Inhibitor | inhibit | GNE-495 | GNE495 | GNE 495 |
| Inhibitors Related | Sodium lauryl sulfoacetate | Phosphocreatine disodium hydrate | Vemurafenib | SKLB-163 | RV01 | Takinib | NG25 | Phosphocreatine disodium | RMM-46 | Oleanolic Acid | Dehydrocostus Lactone | Sodium new houttuyfonate |
| Related Compound Libraries | Reprogramming Compound Library | Pain-Related Compound Library | Bioactive Compound Library | HIF-1 Signaling Pathway Compound Library | Kinase Inhibitor Library | Anti-Obesity Compound Library | Inhibitor Library | Anti-Fibrosis Compound Library | NO PAINS Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | MAPK Inhibitor Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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