一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Journal of Functional Foods >>article
Journal of Functional Foods

Journal of Functional Foods

IF: 3.8
Download PDF

Ginseng-Epimedii formula ameliorated experimental Sj?gren’s syndrome via reducing IL-6 production

Published:23 April 2024 DOI: 10.1016/j.jff.2024.106198
Yacun Chen , Jing Xie , Meiling Wu , Sulan Yu , Jiangang Shen , Xiang Lin

Abstract

Medicinal herbs have been recently investigated to explore their therapeutic potential on autoimmune disorders, as an alternative treatment to relieve disease symptoms. Here, we sought to determine the immunomodulatory function of a Chinese medicine formula Ginseng-Epimedii (GE), constituted by Lycium barbarum, Ginseng, Eleutherococcus senticosus and Epimedium brevicornum, on mice with experimental Sj?gren’s syndrome (ESS). We found that GE-treated ESS mice exhibited improved salivary gland function and decreased serum levels of autoantibodies. In line with the network pharmacology analysis, GE treatment suppressed IL-6 production by B cells and conventional dendritic cells, associated with decreased effector T cell subsets. Using co-culture assay and adoptive transfer model, we demonstrated that splenoctyes from ESS mice receiving GE treatment showed impaired capacity to drive pathogenic Th17 and T follicular helper cell differentiation. Thus, this study suggested the therapeutic potential of GE formula in treating SS, by skewing the microenvironment that unfavored effector T cell responses.

Substances (7)

Materials Related products
Procduct Name CAS Molecular Formula Supplier Price
Betaine 107-43-7 C5H11NO2 1014 suppliers $4.00-$4341.04
Betaine 107-43-7 C5H11NO2 1014 suppliers $4.00-$4341.04
Betaine 107-43-7 C5H11NO2 1014 suppliers $4.00-$4341.04
Betaine 107-43-7 C5H11NO2 1014 suppliers $4.00-$4341.04
Betaine 107-43-7 - Inquiry
Betaine 107-43-7 - Inquiry

Similar articles

IF:5.3

Sinomenine Ameliorated Microglial Activation and Neuropathic Pain After Chronic Constriction Injury Via TGF‐β1/ALK5/Smad3 Signalling Pathway

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Ling Ling, Min Luo,etc Published: 25 November 2024
IF:5.6

AICAR Improves Outcomes of Metabolic Syndrome and Type 2 Diabetes Induced by High-Fat Diet in C57Bl/6 Male Mice.

International Journal of Molecular Sciences Elena A Tukhovskaya, Elvira R Shaykhutdinova,etc Published: 11 December 2022
汽车| 白沙| 平塘县| 普安县| 祁连县| 临高县| 库尔勒市| 桑植县| 花垣县| 诸暨市| 北川| 江都市| 犍为县| 平安县| 三门县| 龙州县| 瓮安县| 台北市| 罗田县| 稷山县| 方城县| 六枝特区| 揭东县| 瑞丽市| 香港| 原阳县| 瑞丽市| 城市| 宣城市| 汨罗市| 鹤壁市| 高淳县| 库伦旗| 丹东市| 延边| 综艺| 台东县| 文水县| 乐山市| 东明县| 罗城|