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Cell and Bioscience

Cell and Bioscience

IF: 6.1
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Generation of musculoskeletal cells from human urine epithelium-derived presomitic mesoderm cells

Published:15 July 2024 DOI: 10.1186/s13578-024-01274-w PMID: 39010176
Huiru Gao,?Xingnan Huang,?Zepo Cai,?Baomei Cai,?Kaipeng Wang,?Junyang Li,?Junqi Kuang,?Bo Wang,?Ziwei Zhai,?Jin Ming,?Shangtao Cao,?Yue Qin,?Duanqing Pei

Abstract

Background: Numerous studies have shown that somite development is a necessary stage of myogenesis chondrogenesis and osteogenesis. Our previous study has established a stable presomitic mesoderm progenitor cell line (UiPSM) in vitro. Naturally, we wanted to explore whether UiPSM cell can develop bone and myogenic differentiation.

Results: Selective culture conditions yielded PAX3 and PAX7 positive skeletal muscle precursors from UiPSM cells. The skeletal muscle precursors undergo in vitro maturation resulting in myotube formation. MYOD effectively promoted the maturity of the skeletal myocytes in a short time. We found that UiPSM and MYOD mediated UiPSM cell-derived skeletal myocytes were viable after transplantation into the tibialis anterior muscle of MITRG mice, as assessed by bioluminescence imaging and scRNA-seq. Lack of teratoma formation and evidence of long-term myocytes engraftment suggests considerable potential for future therapeutic applications. Moreover, UiPSM cells can differentiate into osteoblast and chondroblast cells in vitro.

Conclusions: UiPSM differentiation has potential as a developmental model for musculoskeletal development research and treatment of musculoskeletal disorders.

Substances (6)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Dexamethasone 21-phosphate disodium salt 2392-39-4 C22H28FNa2O8P 596 suppliers $20.00-$3839.41
Dexamethasone 21-phosphate disodium salt 2392-39-4 C22H28FNa2O8P 596 suppliers $20.00-$3839.41
Dexamethasone 21-phosphate disodium salt 2392-39-4 C22H28FNa2O8P 596 suppliers $20.00-$3839.41
Dexamethasone 21-phosphate disodium salt 2392-39-4 C22H28FNa2O8P 596 suppliers $20.00-$3839.41
Dexamethasone Sodium Phosphate 2392-39-4 - Inquiry
Dexamethasone Sodium Phosphate 2392-39-4 - Inquiry

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