一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Cell stem cell >>article
Cell stem cell

Cell stem cell

IF: 19.8
Download PDF

Mitochondrial pyruvate carriers control airway basal progenitor cell function through glycolytic-epigenetic reprogramming

Published:18 October 2024 DOI: 10.1016/j.stem.2024.09.015
Yawen Li, Yalin He, Qi Zheng, Jiazhu Zhang, Xinwen Pan, Xi Zhang, Huairui Yuan, Guangchuan Wang, Xin Liu, Xiaolong Zhou, Xueliang Zhu, Tao Ren, Pengfei Sui

Abstract

Basal cells (BCs) are the progenitor cells responsible for tracheal epithelium integrity. Here, we demonstrate that mitochondrial pyruvate carriers (MPCs) act as metabolic checkpoints that are essential for BC fate decision. Inhibition of MPCs enables long-term expansion of BCs from both mice and humans. Genetic inactivation of Mpc2 in mice leads to BC hyperplasia and reduced ciliated cells during homeostasis, as well as delayed epithelial regeneration and accumulation of intermediate cells following injury. Mechanistically, MPC2 links glycolysis to ATP citrate lyase (ACLY)-dependent cytosolic acetyl-coenzyme A (CoA) generation, which is required for the epigenetic control of differentiation-related gene transcription. Modulating this metabolic-epigenetic axis partially rescues Yes-associated protein (YAP)-dysfunction-induced changes in BCs. Importantly, exogenous citrate promotes the differentiation of BCs from chronic obstructive lung disease (COPD) patients. Thus, beyond demonstrating the role of pyruvate metabolism in BC fate decision, our study suggests that targeting pyruvate-citrate metabolism may serve as a potential strategy to rectify abnormal BC behavior in lung diseases.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Verteporfin 129497-78-5 2C41H42N4O8 251 suppliers $24.00-$4655.00
Verteporfin 129497-78-5 2C41H42N4O8 251 suppliers $24.00-$4655.00
Verteporfin 129497-78-5 2C41H42N4O8 251 suppliers $24.00-$4655.00
Verteporfin 129497-78-5 2C41H42N4O8 251 suppliers $24.00-$4655.00

Similar articles

IF:5.3

Etoposide induces cell death via mitochondrial-dependent actions of p53.

Cancer Cell International Sarwat Jamil, Irene Lam,etc Published: 7 August 2015
IF:2.6

Ammonium lauryl sulfate-induced apoptotic cell death may be due to mitochondrial dysfunction triggered by caveolin-1

Toxicology in Vitro Eun-Jung Park , Eunsol Seong ,etc Published: 1 June 2019
IF:14.3

Calcium Channel Blocker Lacidipine Promotes Antitumor Immunity by Reprogramming Tryptophan Metabolism

Advanced Science Yuwen Sheng, Chong Qiao,etc Published: 25 November 2024
兰西县| 益阳市| 郁南县| 八宿县| 冕宁县| 沧州市| 柳州市| 宜宾市| 安阳市| 招远市| 新郑市| 栾川县| 朝阳市| 阜康市| 安仁县| 加查县| 新蔡县| 宜兰县| 井冈山市| 北碚区| 南汇区| 汉源县| 上蔡县| 锡林浩特市| 信宜市| 香河县| 奉贤区| 德钦县| 襄樊市| 施甸县| 芒康县| 潜山县| 进贤县| 鹤庆县| 凤阳县| 上饶市| 基隆市| 航空| 女性| 迁安市| 新乡县|