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Journal of Hazardous Materials

Journal of Hazardous Materials

IF: 12.2
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Feng Xiaoli. et al. Graphene oxide disrupted mitochondrial homeostasis through inducing intracellular redox deviation and autophagy-lysosomal network dysfunction in SH-SY5Y cells. J Hazard Mater. 2021 Aug;416:126158

Published:15 August 2021 DOI: 10.1016/j.jhazmat.2021.126158 PMID: 34492938
Feng Xiaoli, Zhang Yaqing, Luo Ruhui, Lai Xuan, Chen Aijie, Zhang Yanli, Hu Chen, Chen Lili, Shao Longquan

Abstract

Graphene oxide (GO) nanomaterials have significant advantages for drug delivery and electrode materials in neural science, however, their exposure risks to the central nervous system (CNS) and toxicity concerns are also increased. The current studies of GO-induced neurotoxicity remain still ambiguous, let alone the mechanism of how complicated GO chemistry affects its biological behavior with neural cells. In this study, we characterized the commercially available GO in detail and investigated its biological adverse effects using cultured SH-SY5Y cells. We found that ultrasonic processing in medium changed the oxidation status and surface reactivity on the planar surface of GO due to its hydration activity, causing lipid peroxidation and cell membrane damage. Subsequently, ROS-disrupted mitochondrial homeostasis, resulting from the activation of NOX2 signaling, was observed following GO internalization. The autophagy-lysosomal network was initiated as a defensive reaction to obliterate oxidative damaged mitochondria and foreign nanomaterials, which was ineffective due to reduced lysosomal degradation capacity. These sequential cellular responses exacerbated mitochondrial stress, leading to apoptotic cell death. These data highlight the importance of the structure-related activity of GO on its biological properties and provide an in-depth understanding of how GO-derived cellular redox signaling induces mitochondrion-related cascades that modulate cell functionality and survival.

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Materials
Procduct Name CAS Molecular Formula Supplier Price
Forskolin 66575-29-9 C22H34O7 537 suppliers $12.00-$3200.00
Forskolin 66575-29-9 C22H34O7 537 suppliers $12.00-$3200.00
Forskolin 66575-29-9 C22H34O7 537 suppliers $12.00-$3200.00
Forskolin 66575-29-9 C22H34O7 537 suppliers $12.00-$3200.00
3-ISOBUTYL-1-METHYLXANTHINE 28822-58-4 C10H14N4O2 392 suppliers $10.00-$6135.00
3-ISOBUTYL-1-METHYLXANTHINE 28822-58-4 C10H14N4O2 392 suppliers $10.00-$6135.00
3-ISOBUTYL-1-METHYLXANTHINE 28822-58-4 C10H14N4O2 392 suppliers $10.00-$6135.00
3-ISOBUTYL-1-METHYLXANTHINE 28822-58-4 C10H14N4O2 392 suppliers $10.00-$6135.00
Forskolin 66575-29-9 - Inquiry
Forskolin 66575-29-9 - Inquiry

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