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Life sciences

Life sciences

IF:5.2 CiteScore:12.2 Articles:841
Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.

Identification of EPZ004777 and FG2216 as inhibitors of TGF-β1 induced Treg cells by screening a library of epigenetic compounds

Published: 15 July 2022 DOI: 10.1016/j.lfs.2022.120643
Kavitha Premkumar , Bhavani S. Shankar

STING up-regulates VEGF expression in oxidative stress-induced senescence of retinal pigment epithelium via NF-κB/HIF-1α pathway

Published: 15 March 2022 DOI: 10.1016/j.lfs.2021.120089
Qingqiu Chen , Li Tang , Yi Zhang , Chengyu Wan , Xiuxian Yu , Yuman Dong , Xiaoting Chen , Xueling Wang , Ning Li , Guang Xin , Meixia Zhang , Zhen Chen , Hai Niu , Wen Huang

TNF-α up-regulates Nanog by activating NF-κB pathway to induce primary rat spinal cord astrocytes dedifferentiation

Published: 15 December 2021 DOI: 10.1016/j.lfs.2021.120126
Zhenfei Ding , Ce Dai , Wenshan Shan , Rui Liu , Wei Lu , Weilu Gao , Hui Zhang , Wei Huang , Jianzhong Guan , Zongsheng Yin

TAD1822-7 induces ROS-mediated apoptosis of HER2 positive breast cancer by decreasing E-cadherin in an EphB4 dependent manner

Published: 15 November 2021 DOI: 10.1016/j.lfs.2021.119954
Man Zhu, Xiaoyu Tang, Zhengyan Gong, Wenjuan Tang, Yanmin Zhang

Hydrogen sulfide alleviates the anxiety-like and depressive-like behaviors of type 1 diabetic mice via inhibiting inflammation and ferroptosis

Published: 1 August 2021 DOI: 10.1016/j.lfs.2021.119551
Yi Wang, Shengwen Wang, Yu Xin, Jinyue Zhang, Shaofan Wang, Zhuo Yang, Chunhua Liu

Activation of AMPK restored impaired autophagy and inhibited inflammation reaction by up-regulating SIRT1 in acute pancreatitis

Published: 15 July 2021 DOI: 10.1016/j.lfs.2021.119435
Xiao-Die Wang, Wei-Li Yu , Yun Sun

Screened antipsychotic drugs inhibit SARS-CoV-2 binding with ACE2 in vitro

Published: 1 February 2021 DOI: 10.1016/j.lfs.2020.118889
Jiayu Lu, Yajing Hou, Shuai Ge, Xiangjun Wang, Jue Wang, Tian Hu, Yuexin Lv, Huaizhen He, Cheng Wang

The expression and role of glycolysis-associated molecules in infantile hemangioma

Published: 15 October 2020 DOI:
Jian Chen , Dan Wu , Zuoqing Dong , Anwei Chen , Shaohua Liu

NS8593 inhibits Ca2+ permeant channels reversing mouse airway smooth muscle contraction

Published: 1 December 2019 DOI:
Bei-Bei Liu , Yong-Bo Peng , Wen-Jing Zhang , Xiao-Xue Zhao , Li-Ping Chen , Meng-Su Liu , Ge-Ge Wang , Ya-Jing Liu , Jinhua Shen , Ping Zhao , Lu Xue , Meng-Fei Yu , Weiwei Chen , Li-Qun Ma , Gangjian Qin , Jiapei Dai , Qing-Hua Liu

Pretreatment of CD-1 mice with 4-methylpyrazole blocks toxicity from the gamma-hydroxybutyrate precursor, 1,4-butanediol

Published: 5 July 2002 DOI: 10.1016/S0024-3205(02)01744-7
L.S Quang , M.W Shannon , A.D Woolf , M.C Desai , T.J Maher

Analysis of isethionic acid in mammalian tissues

Published: 15 June 1977 DOI: 10.1016/0024-3205(77)90182-5
Mohamed A. Remtulla, Derek A. Applegarth, Donald G. Clark, Ian H. Williams
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