2,3-Dichloropyrazine synthesis
- Product Name:2,3-Dichloropyrazine
- CAS Number:4858-85-9
- Molecular formula:C4H2Cl2N2
- Molecular Weight:148.98
6863-76-9
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$135.00/0.5 G
4858-85-9
351 suppliers
$6.00/5g
Yield:-
Reaction Conditions:
with trichlorophosphate at 60; for 1 h;Heating / reflux;
Steps:
46.2
3-CHLOROPYRAZINE 1-oxide (D46, Step 1) (2.2 g, 16.9 MMOL) was added slowly to phosphorus oxychloride (10 ml) at 60 °C. When the addition was complete the mixture was heated at reflux for 60 minutes. The mixture was allowed to cool and poured into ice and solid sodium acetate (5 g). This was stirred until the ice had melted and then extracted with DICHLOROMETHANE. The DICHLOROMETHANE extracts were combined, washed with saturated sodium bicarbonate solution, water and brine. The organic portion was dried under sodium sulfate and evaporated in vacuo. The resulting residue was purified by column chromatography ELUTING with a mixture of ethyl acetate: hexane (1: 20) to afford the title compound (0.86 g). 'H NMR (CDCI3) 8.32 (2H, s).
References:
GLAXO GROUP LIMITED WO2004/56369, 2004, A1 Location in patent:Page/Page column 23
14508-49-7
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4858-85-9
351 suppliers
$6.00/5g
931-18-0
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$45.00/10mg
4858-85-9
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290-37-9
339 suppliers
$5.00/5g
4858-85-9
351 suppliers
$6.00/5g
14508-49-7
381 suppliers
$14.00/25g
4858-85-9
351 suppliers
$6.00/5g