ChemicalBook CAS DataBase List 2-Ketoglutaric acid

2-Ketoglutaric acid synthesis

14synthesis methods

Product Name:2-Ketoglutaric acid
CAS Number:328-50-7
Molecular formula:C5H6O5
Molecular Weight:146.1

Synthesis of α-ketoglutaric acid: 225 g of triethyl nitrilotricarboxylate and 600 ml of concentrated hydrochloric acid were mixed and left to pass through. It was concentrated by distillation to 140°C, and the residue was crystallized by cooling to obtain 110-112 g of α-ketoglutaric acid with a yield of 92-93%.

67-47-0 Synthesis

67-47-0
606 suppliers
$5.00/100mg

64-18-6 Synthesis

64-18-6
1144 suppliers
$22.12/250ML

328-50-7
643 suppliers
$6.00/25g

110-15-6 Synthesis

110-15-6
1039 suppliers
$5.00/10g

Yield:328-50-7 22 %Chromat. ，110-15-6 10 %Chromat. ，64-18-6 52 %Chromat.

Reaction Conditions:

with dihydrogen peroxide in water at 59.84; under 760.051 Torr; for 24 h;Schlenk technique;Green chemistry;

Steps:

2.2.1. General procedure for oxidation of furfural, HMF, FuA andFDCA
General procedure: Furfural, HMF, FuA and FDCA oxidation were carried out in aSchlenk glass tube attached with a reflux condenser. In each reactionsolid acid and/or solid base catalyst(s) and reactants wereloaded in the reactor followed by the addition of 30% H2O2 oxidantand water solvent. The reaction was performed with stirring underatmospheric pressure at a range of temperatures. After the reaction,the resultant reaction mixture were diluted 10-20 times withwater and the catalyst was filtered off using Millex-LG 0.20 m.The recovered catalyst was washed by 50 mL of water, and driedin vacuo at room temperature before further reuses.

References:

Choudhary, Hemant;Nishimura, Shun;Ebitani, Kohki [Applied Catalysis A: General,2013,vol. 458,p. 55 - 62]

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88-14-2 Synthesis