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ChemicalBook CAS DataBase List 3,3-Dimethylbutyryl chloride
7065-46-5

3,3-Dimethylbutyryl chloride synthesis

7synthesis methods
Add 3,3-dimethylbutyric acid into the reactor, stir, add phosphorus trichloride, raise the temperature to the reaction temperature for reaction, cool to room temperature after the reaction, and stand for stratification; separate after standing for stratification The phosphorous acid in the lower layer is used as a by-product, and the crude acid chloride in the upper layer is collected under reduced pressure distillation at an absolute pressure of 20KPa to collect a fraction at 79-81°C to obtain 3,3-dimethylbutyryl chloride product.
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: Cr2O3-H2SO4
2: NaOBr
3: SOCl2

References:

Homeyer;Whitmore;Wallingford [Journal of the American Chemical Society,1933,vol. 55,p. 4209,4212]

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