3-Bromobenzyl alcohol synthesis
- Product Name:3-Bromobenzyl alcohol
- CAS Number:15852-73-0
- Molecular formula:C7H7BrO
- Molecular Weight:187.03
3132-99-8
15852-73-0
Example 49: Synthesis of (3-bromophenyl)methanol Sodium borohydride (7.1 g, 186.1 mmol) was added in one batch to a solution of 3-bromobenzaldehyde (114.8 g, 620.4 mmol) in ethanol (650 mL) at 25 °C. The reaction mixture was stirred at room temperature for 1 hour. Upon completion of the reaction, the reaction was quenched with water (200 mL). After ethanol was removed by distillation under reduced pressure, the residue was dissolved in ethyl acetate (500 mL) and filtered. The filtrate was washed sequentially with water (150 mL) and brine (150 mL) and then dried over anhydrous sodium sulfate. After concentration under reduced pressure to remove the solvent, 115.8 g of 3-bromobenzyl alcohol was obtained in 99.8% yield.
3132-99-8
508 suppliers
$5.00/10g
15852-73-0
289 suppliers
$11.00/25g
Yield:15852-73-0 99.8%
Reaction Conditions:
with sodium tetrahydroborate in ethanol at 20 - 25;
Steps:
49 (3-Bromophenyl)methanol
Example 49 (3-Bromophenyl)methanol Sodium borohydride (7.1 g, 186.1 mmol) in several portions was added to a solution of 3-bromobenzaldehyde (114.8 g, 620.4 mmol) in EtOH (650 mL) at 25° C. Then the mixture was stirred for 1 h at room temperature. The reaction was quenched with water (200 mL). After removing EtOH, the residue was dissolved in AcOEt (500 mL), and filtered. The filtrate was washed with water (150 mL), brine (150 mL), and dried over Na2SO4. After removing the solvent, 115.8 g of the title compound was obtained (yield: 99.8%).
References:
Glaxo Group Limited US2009/203657, 2009, A1 Location in patent:Page/Page column 54
618-89-3
273 suppliers
$28.00/5g
15852-73-0
289 suppliers
$11.00/25g
24398-88-7
167 suppliers
$5.00/1g
15852-73-0
289 suppliers
$11.00/25g
585-76-2
377 suppliers
$6.00/5g
15852-73-0
289 suppliers
$11.00/25g
591-17-3
254 suppliers
$10.00/10g
3132-99-8
508 suppliers
$5.00/10g
585-76-2
377 suppliers
$6.00/5g
15852-73-0
289 suppliers
$11.00/25g