3-Fluoroacetanilide synthesis
- Product Name:3-Fluoroacetanilide
- CAS Number:351-28-0
- Molecular formula:C8H8FNO
- Molecular Weight:153.15
372-19-0
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$10.00/1g
64-19-7
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351-28-0
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$10.00/5g
Yield: 83%
Reaction Conditions:
with 1-methyl-3-(4-sulfonylbutyl)-1H-imidazol-3-ium trifluoromethanesulfonate at 90; for 0.166667 h;Microwave irradiation;chemoselective reaction;Temperature;
Steps:
Typical procedure for N-acylation Amines (microwave irradiation):
General procedure: A mixture of amines (0.01 mol), acetic acid (0.015 mol, 1 mL) and [BMIM(SO3H)][OTf] (50 mol %) was introduced into a Biotage microwave oven and heated for 6 to 9 minutes at 90oC. Progress of the reaction was monitored by TLC and GC-MS. After completion of reaction, the reaction mass was cooled at room temperature and poured into ice water. The crystals of N-acylated product so obtained were filtered, washed with of cold ethanol-water mixture (10-15mL) and dried.
References:
Savanur, Hemantkumar M.;Malunavar, Shruti S.;Prabhala, Pavankumar;Sutar, Suraj M.;Kalkhambkar, Rajesh G.;Laali, Kenneth K. [Tetrahedron Letters,2019,vol. 60,# 42,art. no. 151159] Location in patent:supporting information
455-36-7
291 suppliers
$17.00/1g
351-28-0
170 suppliers
$10.00/5g