4-Amino-3-fluorophenol synthesis
- Product Name:4-Amino-3-fluorophenol
- CAS Number:399-95-1
- Molecular formula:C6H6FNO
- Molecular Weight:127.12
394-41-2
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$16.00/1g
399-95-1
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$14.00/5g
Yield:399-95-1 100%
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in tetrahydrofuran;ethanol at 20; for 4.5 h;
Steps:
107
To a solution of 3-fluoro-4-nitrophenol (20 g) in ethanol (200 ml)-tetrahydrofuran (125 ml) was added 10% palladium carbon (6.0 g), followed by stirring under a hydrogen atmosphere at room temperature for 4.5 hrs. The mixture was filtered to remove the catalyst, which was washed with ethanol. The filtrate was concentrated under a reduced pressure to provide the titled compound (16.1 g, 100%) as a pale yellow solid. 1H-NMR Spectrum (DMSO-d6) δ (ppm): 4.38 (2H, m), 6.34 (1H, m), 6.43 (1H, m), 6.59 (1H, dd, J=8.4, 10.4 Hz), 8.78 (1H, s).
References:
US2005/277652,2005,A1 Location in patent:Page/Page column 72-73
1493-27-2
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399-95-1
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$14.00/5g
103842-00-8
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399-95-1
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7784-21-6
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144-55-8
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1493-27-2
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399-95-1
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$14.00/5g
18266-53-0
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399-95-1
428 suppliers
$14.00/5g