4-Iodobenzonitrile synthesis
- Product Name:4-Iodobenzonitrile
- CAS Number:3058-39-7
- Molecular formula:C7H4IN
- Molecular Weight:229.02
A mixed solvent consisting of 0.2 mmol p-iodophenylacetic acid, 0.33 mmol cuprous bromide, 1.0 mL of acetonitrile and DMAc was added to the reactor (volume ratio [2:1]). The reaction was heated to 120 °C under oxygen with continuous stirring for 34 h.
64-17-5
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623-00-7
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3058-39-7
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51934-41-9
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Yield:3058-39-7 80% ，51934-41-9 15%
Reaction Conditions:
with copper(I) oxide;L-proline;potassium iodide at 110; for 30 h;Schlenk technique;Inert atmosphere;Sealed tube;
Steps:
2.2. General procedure for aryl and heteroaryl bromide-iodideexchange reaction
General procedure: A Schlenk tube was charged with Cu2O (7.2 mg, 10 mol%), l-proline (11.5 mg, 20 mol%), aryl (or heteroaryl) bromide (1 or 3,0.50 mmol), potassium iodide (KI) (249 mg, 0.75 mmol), and EtOH(1.5 mL) under nitrogen atmosphere. The Schlenk tube was sealedwith a teflon valve, and then the reaction mixture was stirred at110C for a period (the reaction progress was monitored by GCanalysis). After the reaction was completed, GC yield of high volatileproduct was determined using an appropriate internal standard(chlorobenzene or 1-chloro-4-methylbenzene) or the solvent wasremoved under reduced pressure. The residue obtained was puri-fied via silica gel chromatography (eluent: petroleum ether/ethylacetate = 10/1) to afford aryl iodides 2a-2o or heteroaryl iodides4a-4g.
References:
Feng, Xiujuan;Li, Lingyu;Yu, Xiaoqiang;Yamamoto, Yoshinori;Bao, Ming [Catalysis Today,2016,vol. 274,p. 129 - 132]
873-74-5
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3058-39-7
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126747-14-6
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3058-39-7
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18282-51-4
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3058-39-7
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624-31-7
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3058-39-7
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