4-Methoxy-5-(3-Morpholinopropoxy)-2-nitrobenzaMide synthesis
- Product Name:4-Methoxy-5-(3-Morpholinopropoxy)-2-nitrobenzaMide
- CAS Number:861453-16-9
- Molecular formula:C15H21N3O6
- Molecular Weight:339.34
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Yield:861453-16-9 6.1 g
Reaction Conditions:
with dihydrogen peroxide;potassium carbonate in dimethyl sulfoxide at 50; for 1.5 h;
Steps:
4 Example 42-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzamide(Compound 6)
Compound 5 (6.03 g, 18.8 mmol) was dissolved in dimethyl sulfoxide (32 mL).Add anhydrous potassium carbonate (1.44g, 10.5mmo1), and warm to 50 ° C,A 30% hydrogen peroxide solution (14.3 mL) was slowly added dropwise to control the reaction temperature at about 50 °C.Stirring was continued for 1.5 h, diluted with water (120 mL), and cooled to 15 °C.Filter by suction, wash the filter cake with water, dry,Recrystallization from ethyl acetate gave Compound 6 (6.1 g).
References:
CN109627222,2019,A Location in patent:Paragraph 0030; 0031; 0032
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