4-Methylanisole synthesis
- Product Name:4-Methylanisole
- CAS Number:104-93-8
- Molecular formula:C8H10O
- Molecular Weight:122.16
Yield:104-93-8 99%
Reaction Conditions:
with tetrabutylammomium bromide;potassium carbonateReflux;
Steps:
1.1 (1) Synthesis of Compound I.
Equipped with reflux condenser 1000ml round bottom flask was added 33ml of p-methyl phenol,48.3 g of tetrabutylammonium bromide, 62.1 g of K2C03 and 450 ml of dimethyl carbonate, Warmed to reflux, TLC monitoring of the reaction process; TLC monitoring of raw materials after reaction,Steamed excess dimethyl carbonate, cooled to room temperature, filtration,Dropping the mass concentration of 10% hydrochloric acid to adjust the pH to 5 ~ 6, extracted with dichloromethane,Dry Na2S04 anhydrous, filter, remove the solvent under reduced pressure,Get 36.5g light yellow special smell of oily liquid I,The molar yield is 99%.
References:
Hubei Longxiang Pharmaceutical Technology Co., Ltd.;Chen Qingping;Xu Lingyan;Guo Xichang;Wu Kai;Wu Donglin CN107311938, 2017, A Location in patent:Paragraph 0031; 0032; 0044; 0045
104-47-2
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104-93-8
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