一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 6,8-dichlorooctanoic acid
41443-60-1

6,8-dichlorooctanoic acid synthesis

2synthesis methods
-

Yield:41443-60-1 80%

Reaction Conditions:

with pyridine;sodium hydroxide;thionyl chloride in (2S)-N-methyl-1-phenylpropan-2-amine hydrate;toluene

Steps:

11 EXAMPLE 11
EXAMPLE 11 To a solution of 2.4 g (12.3 mmoles) of (+)-8-chloro-6-hydroxy-octanoic acid (+)-(VI) and 0.05 g (0.6 mmoles) of pyridine in 30 ml toluene, 3.3 g (27.7 mmoles) of thionyl chloride were added slowly. The mixture was then refluxed for 1 hour. The reaction mixture was cooled to room temperature and added to 50 ml ice water. The organic phase was then removed, washed with 20 ml water and stirred for 4 hours with 30 ml of 2N NaOH. The aqueous phase was then removed, adjusted to a pH of 1 with 3N HCl and extracted twice with 20 ml diethylether. The combined ether extracts were dried over magnesium sulfate. After that, the solvent was evaporated under vacuum. (-)-6,8-dichloro-octanoic acid (-)-(VII) was obtained in a yield of 2.1 g (80% of the theoretical yield). [α]D20 =-30.6° (c=1; benzene).

References:

Arzneimittelwerk Dresden GmbH US5731448, 1998, A

FullText

6,8-dichlorooctanoic acid Related Search:

怀柔区| 牙克石市| 香港| 阜新| 肥西县| 兰西县| 浦北县| 赤壁市| 长葛市| 玉环县| 新沂市| 日土县| 新源县| 金华市| 赞皇县| 南安市| 闵行区| 黔江区| 凌海市| 临颍县| 阿坝县| 黔东| 基隆市| 枣阳市| 平江县| 剑河县| 平安县| 丹东市| 鄯善县| 营山县| 陆良县| 尚志市| 得荣县| 扎兰屯市| 寿阳县| 桦川县| 方山县| 湘潭县| 农安县| 金山区| 古田县|