N-(Methoxymethyl)-N-(trimethylsilylmethyl)benzylamine synthesis
- Product Name:N-(Methoxymethyl)-N-(trimethylsilylmethyl)benzylamine
- CAS Number:93102-05-7
- Molecular formula:C13H23NOSi
- Molecular Weight:237.41
50-00-0
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![N-[(Trimethylsilyl)methyl]benzylamine](/CAS/GIF/53215-95-5.gif)
53215-95-5
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93102-05-7
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Yield:93102-05-7 97.5%
Reaction Conditions:
Stage #1: formaldehyd;N-(trimethylsilylmethyl)benzylamine in water at 0;
Stage #2: with potassium carbonate in water at 20; for 2 h;
Steps:
Intermediate P16: N-Benzyl-1 -methoxy-N-[(trimethylsilyl)methyl]methanamine
To the solution of formaldehyde (37%, 16.816 g, 207.19 mmol) at 0°C N-benzylo- 1 -(trimethylsilyl)methanamine (Intermediate P15, 28.588 g, 144.89 mmol) was added dropwise. To the mixture solid potassium carbonate (16.182 g, 115.91 mmol) was added and the whole was stirred at room temperature for 2 hours. Water (50 ml) was added and the mixture was extracted with diethyl ether (2 x 50 ml). Organic layer was washed with brine and dried over sodium sulphate. Solvent and drying agent were removed to obtain 33.551 g of the title product in the form of a yellow oil (yield 97.5%). 1H NMR (300 MHz, CDCl3): δ 7.35 - 7.18 (m, 5H), 3.99 (s, 2H), 3.75 (s, 2H), 3.22 (s, 3H), 2.18 (s, 2H), 0.13 (s, 9H).
References:
WO2014/24125,2014,A1 Location in patent:Page/Page column 24-25
67-56-1
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50-00-0
906 suppliers
$10.00/25g
53215-95-5
157 suppliers
$11.00/1g
93102-05-7
323 suppliers
$6.00/1g
67-56-1
803 suppliers
$9.00/25ml
53215-95-5
157 suppliers
$11.00/1g
93102-05-7
323 suppliers
$6.00/1g
53215-95-5
157 suppliers
$11.00/1g
107-30-2
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93102-05-7
323 suppliers
$6.00/1g