一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Fluoxetine hydrochloride
56296-78-7

Fluoxetine hydrochloride synthesis

8synthesis methods
A method for the synthesis of fluoxetine hydrochloride was developed by the Mannich reaction of acetophenone with methylamine hydrochloride, paraformaldehyde to form 3-methylamino-1-phenylacetic acid hydrochloride, followed by the preparation of 3-methylamino-I-phenylpropanol in methanol with potassium borohydride reductant, followed by etherification and salt formation to synthesize the antidepressant fluoxetine monohydrochloride.
Synthesis of Fluoxetine
Fluoxetine is the active ingredient in the antidepressant Prozac. It works as a selective serotonin reuptake inhibitor to treat conditions including depression and obsessive-compulsive disorder. To assemble this molecule, a three-step synthesis was utilized. Intermediates included 1- propanone, 3-(methylamino)-1-phenyl-(synthesized through an SN2 reaction between 3-chloropropiophenone and methylamine) and α-[2- (methylamino) ethyl] benzyl alcohol (synthesized through reduction of the first intermediate using NaBH4). The second intermediate was subjected to 4-chlorobenzotrifluoride and sodium hydride to produce the desired molecule, fluoxetine.
-

Yield:-

Reaction Conditions:

Stage #1: 3-methylamino-1-phenylpropan-1-ol;4-Iodobenzotrifluoridewith caesium carbonate;copper(I) bromide in xylenes at 130; for 16 h;
Stage #2: with hydrogenchloride in tert-butyl methyl ether;isopropyl alcohol;xylenes at 20;

Steps:

4 EXAMPLE 4

A mixture of N-methyl-3-hydroxy-3-phenylpropylamine (1.65 g, 10 mmol), 4-iodobenzotrifluoride (3.25 g, 12 mmol), cuprous bromide (0.17 g), cesium carbonate (3.9 g, 12 mmol) and xylenes (1 mL) was stirred under nitrogen at 130° C. until reaction completion as determined by 1H NMR (16 hours). The reaction mixture was cooled to room temperature, diluted with methyl t-butyl ether (20 mL), filtered, and rinsed with more methyl t-butyl ether. 20% HCl solution in isopropanol (3 mL) was added and the resulting solution was evaporated to dryness to yield a solid residue. The residue was stirred with methyl t-butyl ether (20 mL) for 1 hour at room temperature and the suspension was filtered and washed with more methyl t-butyl ether to give 2.4 g of N-methyl-3-(4-trifluoromethylphenoxy)-3-phenylpropylamine hydrochloride (Fluoxetine hydrochloride) as a white solid. 1H NMR spectrum of the product is identical to that of Example 3.

References:

US2007/10678,2007,A1 Location in patent:Page/Page column 7

Fluoxetine hydrochloride Related Search:

丰宁| 嘉义市| 屏山县| 璧山县| 大埔县| 吉安县| 柘荣县| 邵阳市| 昆明市| 平遥县| 清新县| 合作市| 木里| 安西县| 高邑县| 宁蒗| 尼木县| 景宁| 延边| 阿拉善盟| 松江区| 青铜峡市| 南城县| 双桥区| 江城| 义乌市| 灯塔市| 山阳县| 阜平县| 宁波市| 呼图壁县| 霸州市| 麟游县| 贵定县| 贵港市| 通州市| 黄石市| 金乡县| 民乐县| 临江市| 宁远县|