Fmoc-L-phenylglycine synthesis
- Product Name:Fmoc-L-phenylglycine
- CAS Number:102410-65-1
- Molecular formula:C23H19NO4
- Molecular Weight:373.4
2935-35-5
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28920-43-6
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102410-65-1
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$5.00/1g
Yield:-
Reaction Conditions:
in ethanol;water at 60; for 2 h;
Steps:
1
An unprotected bait, (S)-Aminophenylacetic acid, was protected with (9H- Fluoren-9-yl)methyl chloroformate (Fmoc chloride). To the mixture of the two solids, (S)- Aminophenylacetic acid (1 mmol) and Fmoc chloride (1.2 mmol), 1.5 mL of a 3:1 mixture of water to ethanol was added. The resulting solution was stirred at 60 C for 2 hours. The solution was acidified with HCl (1M) until pH 4-5 at O C and extracted with EtOAc (3 X 10 mL). The combined organic layers were merged dried over sodium sulfate and concentrated in vacuo to afford the protected bait, (S)-[(9H-Fluoren-9-yl)methoxycarbonyl- amino]phenylacetic acid. In this example the protected bait can also be purchased commercially from a number of vendors.
References:
WO2021/167770,2021,A1 Location in patent:Paragraph 00153-00154
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82911-69-1
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102410-65-1
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$5.00/1g
2835-06-5
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102410-65-1
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111524-95-9
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$6.00/1g
28920-43-6
553 suppliers
$5.00/5g
102410-65-1
223 suppliers
$5.00/1g
111524-95-9
202 suppliers
$6.00/1g