Niclosamide synthesis
- Product Name:Niclosamide
- CAS Number:50-65-7
- Molecular formula:C13H8Cl2N2O4
- Molecular Weight:327.12
Yield:50-65-7 68.7%
Reaction Conditions:
with phosphorus trichloride in chlorobenzene at 135; for 3 h;Concentration;Solvent;
Steps:
1 Synthesis step 1: preparation N-(2-chloro-4-nitro-phenyl) - 5-chloro-2-hydroxy-benzamide
In 135 °C, to the 5- chlorine salicylic acid (3.44g, 20 . 0mmol) and 2-chloro-4-nitroaniline (3.44g, 20 . 0mmol) dissolved in chlorobenzene mixing solution of adding dropwise PCl3(2.4g, 17 . 5mmol) dissolved in a chlorobenzene solution. 3 hours later, the reaction solution is cooled to the room temperature. Filtering and collecting the resulting solid, wash, then from ethyl acetate (or acetone) recrystallization to obtain a white solid (6.8g, 68.7%) shaped N-(2-chloro-4-nitro-phenyl) - 5-chloro-2-hydroxy-benzamide.
References:
CN105566147,2016,A Location in patent:Paragraph 0063; 0064; 0065
6626-92-2
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