Nitazoxanide synthesis
- Product Name:Nitazoxanide
- CAS Number:55981-09-4
- Molecular formula:C12H9N3O5S
- Molecular Weight:307.28
121-66-4
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5538-51-2
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55981-09-4
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Yield:55981-09-4 85 %
Reaction Conditions:
with triethylamine in dichloromethane at 40 - 50;Solvent;
Steps:
1-2; 2 Preparation of nitazoxanide
Add 13.78g (0.095mol) of 2-amino-5-nitrothiazole, 27.55g (0.19mol) of o-acetylsalicyloyl chloride, and 460ml of dichloromethane into a 500ml four-neck flask, stir, and add 19.19g of triethylamine dropwise (0.19mol), the dropwise addition was completed, and the reaction was carried out at 40-50°C for 2 hours.HPLC detects that the basic reaction of raw materials is complete.200ml of water was added dropwise, stirred and crystallized for 1 hour, suction filtered and dried to obtain 24.81g of light yellow solid with a yield of 85%.
References:
CN115504941,2022,A Location in patent:Paragraph 0047-0067
121-66-4
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50-78-2
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55981-09-4
414 suppliers
$5.00/10mg