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ChemicalBook CAS DataBase List (S)-Timolol maleate
26921-17-5

(S)-Timolol maleate synthesis

6synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: 75 percent / potassium tert-butoxide / 2-methyl-propan-2-ol / 12 h / 25 °C
2: 90 percent / aq. NaOH / methanol / 8 h
3: tetrahydrofuran / 1 h / 25 °C

References:

Narina, Srinivasarao V.;Sudalai, Arumugam [Tetrahedron,2007,vol. 63,# 14,p. 3026 - 3030]

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