Trifluorothymine synthesis
- Product Name:Trifluorothymine
- CAS Number:54-20-6
- Molecular formula:C5H3F3N2O2
- Molecular Weight:180.08
Yield:54-20-6 91.9%
Reaction Conditions:
with sodium peroxodisulphate;copper(II) sulphate in lithium hydroxide monohydrate at 60 - 65; for 6 h;Temperature;Reagent/catalyst;
Steps:
1-8 Example 1
With a thermometer,11.2 g of uracil (0.1 mol) was added to the reaction vessel of the stirrer.23.4 g of sodium trifluoromethylsulfinate (0.15 mol), dissolved in 150 ml of water,Raise the temperature to 60 ° C, control the reaction temperature at 60 ~ 65 ° C,Add 50 grams of sodium persulfate and 5 grams in batchesThrough a mixture of copper sulfate,After reacting for 6 hours, after evaporating 100 ml of water,It was cooled and precipitated, and dried by filtration to obtain 14.7 g of 5-trifluoromethyluracil (I). HPLC was more than 99%.The yield was 91.9%.
References:
CN108503592,2018,A Location in patent:Page/Page column 3-6
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