Vatalanib base synthesis
- Product Name:Vatalanib base
- CAS Number:212141-54-3
- Molecular formula:C20H15ClN4
- Molecular Weight:346.81
87-41-2
483 suppliers
$6.00/10g
212141-54-3
140 suppliers
$9.00/1mg
Yield:-
Steps:
Multi-step reaction with 3 steps
1: 52 percent / CH3ONa / methanol; various solvent(s) / 2.5 h / 65 °C
2: 82 percent / NH2NH2*H2O / 8 h / 110 °C
3: 82 percent / P2O5; Et3N*HCl / 2 h / 170 °C
References:
Bold, Guido;Altmann, Karl-Heinz;Frei, Joerg;Lang, Marc;Manley, Paul W.;Traxler, Peter;Wietfeld, Bernhard;Brueggen, Josef;Buchdunger, Elisabeth;Cozens, Robert;Ferrari, Stefano;Furet, Pascal;Hofmann, Francesco;Martiny-Baron, Georg;Mestan, Juergen;Roesel, Johannes;Sills, Matthew;Stover, David;Acemoglu, Figan;Boss, Eugen;Emmenegger, Rene;Laesser, Laurent;Masso, Elvira;Roth, Rosemarie;Schlachter, Christian;Vetterli, Werner;Wyss, Dominique;Wood, Jeanette M. [Journal of Medicinal Chemistry,2000,vol. 43,# 12,p. 2310 - 2323]
106-47-8
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$5.00/5 g
107558-48-5
67 suppliers
$39.79/250mg
212141-54-3
140 suppliers
$9.00/1mg
106-47-8
483 suppliers
$5.00/5 g
101094-85-3
37 suppliers
$125.09/10 mg
212141-54-3
140 suppliers
$9.00/1mg
91-15-6
277 suppliers
$13.00/50g
212141-54-3
140 suppliers
$9.00/1mg
67592-40-9
59 suppliers
$205.00/250mg
212141-54-3
140 suppliers
$9.00/1mg