82702-31-6
82702-31-6 結(jié)構(gòu)式
基本信息
Methyl 3-bromo-4-fluorobenzene
METHYL 3-BROMO-4-FLUOROBENZOATE
3-bromo-4-fluoro-2-methylbenzoate
Methyl3-bromo-4-fluorobenzoate98%
Methyl 3-bromo-4-fluorobenzoate 98%
3-BROMO-4-FLUORO-BENZOIC ACID METHYL ESTER
Benzoic acid, 3-bromo-4-fluoro-, methyl ester
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
67-56-1
1007-16-5
82702-31-6
a) 3-溴-4-氟苯甲酸甲酯的合成 將3-溴-4-氟苯甲酸（3.33 g，15.2 mmol）溶解于甲醇（30 mL）中，冰浴冷卻下緩慢滴加乙酰氯（4.3 mL，60.8 mmol）。反應(yīng)混合物于室溫?cái)嚢?0小時(shí)。反應(yīng)完成后，將反應(yīng)液減壓濃縮。粗產(chǎn)物通過(guò)硅膠柱色譜法（洗脫劑：己烷/乙酸乙酯）純化，得到3-溴-4-氟苯甲酸甲酯（3.2 g，收率90%）為無(wú)色油狀物。1H-NMR (CDCl3) δ: 3.92 (3H, s), 7.18 (1H, dd, J = 8.0, 8.2 Hz), 7.99 (1H, ddd, J = 1.9, 4.9, 8.0 Hz), 8.27 (1H, dd, J = 1.9, 6.5 Hz)。
參考文獻(xiàn)：
[1] European Journal of Medicinal Chemistry, 2007, vol. 42, # 11-12, p. 1334 - 1357
[2] Patent: US2010/280013, 2010, A1. Location in patent: Page/Page column 16
[3] Journal of Enzyme Inhibition and Medicinal Chemistry, 2012, vol. 27, # 5, p. 658 - 665,8
[4] Patent: WO2007/99171, 2007, A2. Location in patent: Page/Page column 55
[5] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 3, p. 358 - 362