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ChemicalBook >> CAS DataBase List >> LY2811376

LY2811376

$44 - $6060
Product name: LY2811376
CAS: 1194044-20-6
MF: C15H14F2N4S
MW: 320.36
EINECS:-0
MDL Number:MFCD18074525
Synonyms:LY2811376;(4S)-4-[2,4-Difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-4H-1,3-thiazin-2-amine;LY 2811376,(4S)-4-[2,4-Difluoro-5-(5-pyriMidinyl)phenyl]-5,6-dihydro-4-Methyl-4H-1,3-thiazin-2-aMine;(S)-4-(2,4-difluoro-5-(pyriMidin-5-yl)phenyl)-4-Methyl-5,6-dihydro-4H-1,3-thiazin-2-aMine;(4S)-4-(2,4-difluoro-5-pyriMidin-5-ylphenyl)-4-Methyl-5,6-dihydro-1,3-thiazin-2-aMine;N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride Tubastatin A HCl LY2811376;LY2811376, >=98%;CS-1893

Price88 Properties Safety Information Description

88 prices

Selected condition：

Brand

aablocks
ACHEMBLOCK
AK Scientific
American Custom Chemicals Corporation
ApexBio Technology
Arctom
Axon Medchem
Biorbyt Ltd
Biosynth
Cayman Chemical
Chemenu
ChemScene
Crysdot
DC Chemicals
Matrix Scientific
Medical Isotopes, Inc.
Synthonix
TRC
Usbiological

Package

2x5mg
200mg
250mg
10mM*1mLinDMSO(Solution)
2.5mg
250.00mg
1.00g
10mM*1mLinDMSO
10mM*1mLinDMSO(Solid+Solvent)
1mg
5mg
10mg
25mg
50mg
100MG
1G
10mM(1mLinDMSO)

Manufactureraablocks
Product numberAA000IN9
Product description(4S)-4-[2,4-Difluoro-5-(pyrimidin-5-yl)phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine
Packaging1mg
Price$59
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA000IN9
Product description(4S)-4-[2,4-Difluoro-5-(pyrimidin-5-yl)phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine ≥99%
Packaging5mg
Price$72
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA000IN9
Product description(4S)-4-[2,4-Difluoro-5-(pyrimidin-5-yl)phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine 98+%
Packaging10mg
Price$107
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA000IN9
Product description(4S)-4-[2,4-Difluoro-5-(pyrimidin-5-yl)phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine 98+%
Packaging25mg
Price$171
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA000IN9
Product description(4S)-4-[2,4-Difluoro-5-(pyrimidin-5-yl)phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine 98+%
Packaging50mg
Price$274
Updated2026-05-25
Buy

ManufacturerACHEMBLOCK
Product number10349
Product descriptionLY2811376 98%
Packaging25MG
Price$470
Updated2026-05-25
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ManufacturerACHEMBLOCK
Product number10349
Product descriptionLY2811376 98%
Packaging25MG
Price$470
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product number10349
Product descriptionLY2811376 98%
Packaging100MG
Price$1010
Updated2026-05-25
Buy

ManufacturerACHEMBLOCK
Product number10349
Product descriptionLY2811376 98%
Packaging100MG
Price$1010
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product number10349
Product descriptionLY2811376 98%
Packaging1G
Price$6060
Updated2026-05-25
Buy

ManufacturerACHEMBLOCK
Product number10349
Product descriptionLY2811376 98%
Packaging1G
Price$6060
Updated2026-05-27
Buy

ManufacturerAK Scientific
Product numberY0285
Product descriptionLY2811376
Packaging1mg
Price$96
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberAPI0008041
Product descriptionLY2811376 95.00%
Packaging1MG
Price$148.05
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberAPI0008041
Product descriptionLY2811376 95.00%
Packaging5MG
Price$500.28
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberA4020
Product descriptionLY2811376
Packaging5mg
Price$169
Updated2026-05-06
Buy

ManufacturerApexBio Technology
Product numberA4020
Product descriptionLY2811376
Packaging50mg
Price$919
Updated2026-05-06
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA000IN9	(4S)-4-[2,4-Difluoro-5-(pyrimidin-5-yl)phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine	1mg	$59	2026-05-25	Buy
aablocks	AA000IN9	(4S)-4-[2,4-Difluoro-5-(pyrimidin-5-yl)phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine ≥99%	5mg	$72	2026-05-25	Buy
aablocks	AA000IN9	(4S)-4-[2,4-Difluoro-5-(pyrimidin-5-yl)phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine 98+%	10mg	$107	2026-05-25	Buy
aablocks	AA000IN9	(4S)-4-[2,4-Difluoro-5-(pyrimidin-5-yl)phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine 98+%	25mg	$171	2026-05-25	Buy
aablocks	AA000IN9	(4S)-4-[2,4-Difluoro-5-(pyrimidin-5-yl)phenyl]-4-methyl-5,6-dihydro-1,3-thiazin-2-amine 98+%	50mg	$274	2026-05-25	Buy
ACHEMBLOCK	10349	LY2811376 98%	25MG	$470	2026-05-25	Buy
ACHEMBLOCK	10349	LY2811376 98%	25MG	$470	2026-05-27	Buy
ACHEMBLOCK	10349	LY2811376 98%	100MG	$1010	2026-05-25	Buy
ACHEMBLOCK	10349	LY2811376 98%	100MG	$1010	2026-05-27	Buy
ACHEMBLOCK	10349	LY2811376 98%	1G	$6060	2026-05-25	Buy
ACHEMBLOCK	10349	LY2811376 98%	1G	$6060	2026-05-27	Buy
AK Scientific	Y0285	LY2811376	1mg	$96	2021-12-16	Buy
American Custom Chemicals Corporation	API0008041	LY2811376 95.00%	1MG	$148.05	2021-12-16	Buy
American Custom Chemicals Corporation	API0008041	LY2811376 95.00%	5MG	$500.28	2021-12-16	Buy
ApexBio Technology	A4020	LY2811376	5mg	$169	2026-05-06	Buy
ApexBio Technology	A4020	LY2811376	50mg	$919	2026-05-06	Buy

Next Last

Properties

Boiling point :486.5±55.0 °C(Predicted)
Density :1.42
storage temp. :Store at -20°C
solubility :Soluble in DMSO
form :crystalline solid
pka :5.60±0.40(Predicted)
color :White to khaki
InChI :InChI=1S/C15H14F2N4S/c1-15(2-3-22-14(18)21-15)11-4-10(12(16)5-13(11)17)9-6-19-8-20-7-9/h4-8H,2-3H2,1H3,(H2,18,21)/t15-/m0/s1
InChIKey :MJQMRGWYPNIERM-HNNXBMFYSA-N
SMILES :S1CC[C@](C2=CC(C3=CN=CN=C3)=C(F)C=C2F)(C)N=C1N

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P264	Wash hands thoroughly after handling.
P264	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352	IF ON SKIN: wash with plenty of soap and water.
P304+P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321	Specific treatment (see … on this label).
P330	Rinse mouth.
P332+P313	IF SKIN irritation occurs: Get medical advice/attention.
P337+P313	IF eye irritation persists: Get medical advice/attention.
P403+P233	Store in a well-ventilated place. Keep container tightly closed.
P405	Store locked up.
P501	Dispose of contents/container to..…

Description

Accumulation of the β-amyloid (Aβ) peptide in the brain is implicated as the primary cause of neurodegeneration and progression of Alzheimer’s disease. Aβ is derived from sequential proteolytic cleavage of the amyloid precursor protein (APP) by β-secretase (BACE) and γ-secretase. LY2811376 is a non-peptide inhibitor of BACE1 (IC50 = 239 nM for the synthetic peptide) that demonstrates ~10-fold selectivity over BACE2 and >50-fold selectivity over the aspartyl proteases cathepsin D, pepsin, and renin. LY2811376 treatment in APP-overexpressing cells and transgenic animal models yields a dose-dependent decrease in Aβ. Furthermore, LY2811376 has been reported to reduce C99 and sAPPβ, the two primary APP cleavage products generated by BACE1.

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Suppliers and manufacturers

PNP Biotech Co. Ltd

(4S)-4-[2,4-Difluoro-5-(5-pyrimidinyl)phenyl]-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine CAS:1194044-20-6

career henan chemical co

$2.00
LY2811376 CAS:1194044-20-6

TargetMol Chemicals Inc.

$48.00
LY2811376 CAS:1194044-20-6

Capot Chemical Co.,Ltd.

Biochempartner

Alchem Pharmtech,Inc.

CONIER CHEM AND PHARMA LIMITED

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Dideu Industries Group Limited

Zhejiang J&C Biological Technology Co.,Limited

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LY2811376

Properties

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Description

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