那可汀
| 中文名稱 | 那可汀 |
|---|---|
| 中文同義詞 | 那可汀;(S,R)-諾司卡品;諾司卡品;(S,R)-那可汀;納可丁;那可汀[鹼];諾斯卡品;那可丁 USP標(biāo)準(zhǔn)品 |
| 英文名稱 | Narcotine |
| 英文同義詞 | Capval;Coscopin;Coscotabs;dl-Narcotine [dl-form];Gnoscopine [dl-form];Hederix (free base);Key-Tusscapine;l-alpha-2-methyl-8-methoxy-6,7-methylenedioxy-1-(6,7-dimethoxy-3-phthalidyl)-1 |
| CAS號 | 128-62-1 |
| 分子式 | C22H23NO7 |
| 分子量 | 413.42 |
| EINECS號 | 204-899-2 |
| 相關(guān)類別 | 鎮(zhèn)咳藥物;標(biāo)準(zhǔn)品;化工原料;醫(yī)藥原料藥;Intermediates & Fine Chemicals;Pharmaceuticals;Asymmetric Synthesis;Chiral Building Blocks;Complex Molecules;FINACEAE |
| Mol文件 | 128-62-1.mol |
| 結(jié)構(gòu)式 |  |
那可汀 性質(zhì)
| 熔點 | 174-176 °C(lit.) |
|---|---|
| 比旋光度 | -200 º (c=1 in chloroform) |
| 沸點 | 532.6°C (rough estimate) |
| 密度 | 1.395 |
| 折射率 | 1.5614 (estimate) |
| 儲存條件 | -20°C Freezer, Under Inert Atmosphere |
| 溶解度 | 幾乎不溶于水，溶于丙酮，微溶于乙醇（96%）。溶于強酸；用水稀釋溶液時，堿可能會沉淀。 |
| 形態(tài) | Solid |
| 酸度系數(shù)(pKa) | 7.8(at 25℃) |
| 顏色 | 正交棱鏡或粗針 |
| 旋光度 (Optical Rotation) | [α]20/D 200°, c = 1 in chloroform |
| 水溶解性 | 302.9mg/L(25 ºC) |
| Merck | 13,6752 |
| NIST化學(xué)物質(zhì)信息 | Narcotine alkaloid(128-62-1) |
| EPA化學(xué)物質(zhì)信息 | 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (3S)- (128-62-1) |
Sigma opioid receptors Bradykinin Apoptosis
Noscapine (0-1000 μM; 0-96 hours; rat C6 glioma cells) treatment inhibits cell viability of rat C6 glioma in vitro in a dose- and time-dependent manner. Noscapine inhibits the viability of rat C6 glioma cells with an IC
50
of 250 μM at 72 hours.
Noscapine exposure causes abnormal S-phase reentry, increases mitotic arrest and results in excessive DNA accumulation.
Cylindromatosis increases the ability of noscapine to induce mitotic arrest and apoptosis. Cylindromatosis enhances the effect of noscapine on microtubule polymerization and promotes noscapine binding to microtubules.
Cell Viability Assay
| Cell Line: | Rat C6 glioma cells |
| Concentration: | 0 μM, 0.1 μM, 1 μM, 2 μM, 10 μM, 50 μM, 100 μM, 1000 μM |
| Incubation Time: | 0 hours, 12 hours, 24 hours, 48 hours, 72 hours, 96 hours |
| Result: | Inhibited cell viability of rat C6 glioma in vitro in a dose- and time-dependent manner. |
Noscapine (300?mg/kg; oral gavage; daily; for 15 days; athymic female mice) treatment reduces tumor growth in mice.
| Animal Model: | Athymic female mice (nu/nu) (8-week-old) injected with rat C6 glioma cells |
| Dosage: | 300?mg/kg |
| Administration: | Oral gavage; daily; for 15 days |
| Result: | Revealed a significant reduction of tumor volume. |
安全信息
| 危險品標(biāo)志 | Xn |
|---|---|
| 危險類別碼 | 22 |
| 安全說明 | 24/25 |
| 危險品運輸編號 | 1544 |
| WGK Germany | 3 |
| RTECS號 | RD2625000 |
| 危險等級 | 6.1(b) |
| 包裝類別 | III |
| 海關(guān)編碼 | 29329990 |
| 毒害物質(zhì)數(shù)據(jù) | 128-62-1(Hazardous Substances Data) |
| 毒性 | cyt-ham:lng 100 mg/L ATSUDG (4),41,80 |
| 提供商 | 語言 |
|---|---|
|
英文
|