2,4,6-Trimethylbenzoic acid synthesis
- Product Name:2,4,6-Trimethylbenzoic acid
- CAS Number:480-63-7
- Molecular formula:C10H12O2
- Molecular Weight:164.2
487-68-3
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$6.00/5g
480-63-7
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$6.00/5g
Yield:480-63-7 90%
Reaction Conditions:
with tris[2-(4,6-difluorophenyl)pyridinato-C2,N]-iridium(III);oxygen in acetonitrile at 20;Irradiation;Sealed tube;Green chemistry;chemoselective reaction;
Steps:
Synthesis of carboxylic acids
General procedure: An oven-dried resealable test tube equipped with a magnetic stir bar was charged withaldehyde (1.0 mmol), Ir(dFppy)3 (0.005-0.01 mmol), and MeCN (4.0 mL, 0.25 M). Oxygen wasthen bubbled through the reaction mixture and sealed with a silicone septa screw-cap. A balloonfilled with oxygen was attached to the tube, and the test tube was placed under blue LEDs atroom temperature. The reaction was allowed to proceed for 3-12 h, and reaction progress waschecked by TLC. The solvent was removed under vacuum, and the corresponding carboxylic acidwas purified by flash silica gel chromatography.
References:
Iqbal, Naeem;Choi, Sungkyu;You, Youngmin;Cho, Eun Jin [Tetrahedron Letters,2013,vol. 54,# 46,p. 6222 - 6225] Location in patent:supporting information
124-38-9
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108-67-8
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480-63-7
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4028-63-1
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124-38-9
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480-63-7
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$6.00/5g
4170-90-5
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$11.00/250mg
480-63-7
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$6.00/5g
124-38-9
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$175.00/23402
50827-54-8
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480-63-7
323 suppliers
$6.00/5g