2-Methyl-4-nitroaniline synthesis
- Product Name:2-Methyl-4-nitroaniline
- CAS Number:99-52-5
- Molecular formula:C7H8N2O2
- Molecular Weight:152.15
95-53-4
463 suppliers
$10.00/1g
99-52-5
284 suppliers
$5.00/5 g
Yield:99-52-5 55.9%
Reaction Conditions:
Stage #1:o-toluidine with acetic anhydride;acetic acid at 140; for 4.2 h;
Stage #2: with nitric acid; pH=7 for 5 h;
Stage #3: with sulfuric acid; pH=7 for 3 h;
Steps:
1 Example 1
In a 250 ml reaction bottle, put 100 g of glacial acetic acid and 25.5 g of acetic anhydride.10.7 g of o-toluidine was added dropwise, the temperature was raised to 140 ° C, and the reaction was carried out for 4.2 hours.Add 11g of nitric acid for cooling, react for 5 hours, add purified water,Adjust pH = 7 with liquid alkali, precipitate solid, suction filter, stir the filter cake with water,Add 60g of concentrated sulfuric acid dropwise, hold for 3 hours, cool down, add liquid alkali to adjust pH = 7,Precipitate the solid and dry to obtain 8.5 g of product, yield 55.9%Melting point is 127.3 ~ 128 ° C.
References:
Wang Xiaoqiao;Wang Cunliang;Xu Lingyan;Yan Xuewen;Huang Huanjun CN110642723, 2020, A Location in patent:Paragraph 0008
99-08-1
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$5.00/5 g
99-52-5
284 suppliers
$5.00/5 g
619-15-8
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$180.00/100mg
99-52-5
284 suppliers
$5.00/5 g
95-70-5
189 suppliers
$51.00/5g
99-52-5
284 suppliers
$5.00/5 g