4-ACETYLBENZALDEHYDE synthesis
- Product Name:4-ACETYLBENZALDEHYDE
- CAS Number:3457-45-2
- Molecular formula:C9H8O2
- Molecular Weight:148.16
Yield: 83%
Reaction Conditions:
with sodium formate in N,N-dimethyl-formamide at 120; under 760.051 Torr; for 11 h;
Steps:
Synthesis of aromatic aldehydes
General procedure: A 50 mL round-bottomed flask, equipped with a gas inlet tube, a refluxcondenser and a magnetic stirring bar was charged with MCM-41-2PPdCl2 (102 mg, 0.05 mmol Pd), aryl halide (5.0 mmol) and HCOONa(7.5 mmol). The flask was flushed with CO. DMF (5 mL) was addedby syringe and a slow stream of CO was passed into the suspension.The mixture was vigorously stirred at 110-130 °C for 2-20 h, cooledto room temperature and diluted with diethyl ether (50 mL). Thepalladium catalyst was separated from the mixture by filtration,washed with distilled water (2 × 10 mL), ethanol (2 × 10 mL) and ether(2 × 10 mL) and reused in the next run. The ethereal solution waswashed with water (3 × 20 mL), and dried over anhydrous magnesiumsulfate and concentrated under reduced pressure. The residue waspurified by flash column chromatography on silica gel (hexane-ethylacetate = 10 : 1).
References:
Jiang, Jianwen;Wang, Pingping;Cai, Mingzhong [Journal of Chemical Research,2014,vol. 38,# 4,p. 218 - 222]
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