4-Cyclohexylphenol synthesis
- Product Name:4-Cyclohexylphenol
- CAS Number:1131-60-8
- Molecular formula:C12H16O
- Molecular Weight:176.25
The hydroalkylation of phenol in the presence of palladium catalyst and fused salt (NaCl-AlCl3) under hydrogen pressure was carried out. By using 1% Pd-Al2O3 (1 g) and the fused salt (1 : 1 mol ratio, 6 g), 4-cyclohexylphenol was obtained selectively from 1 (30 g) in a yield of 31.9% at 120°C for 4.5 h.
106-41-2
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1131-60-8
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Yield:-
Steps:
Multi-step reaction with 2 steps
1.1: methyllithium / tetrahydrofuran; diethyl ether / 1 h / -30 °C
1.2: 0.25 h / -30 °C
1.3: 1 h / -30 °C
2.1: Martins sulfurane / tetrahydrofuran; diethyl ether; pentane / -30 °C
References:
Wilson, Claire M.;Ganesh, Venkataraman;Noble, Adam;Aggarwal, Varinder K. [Angewandte Chemie - International Edition,2017,vol. 56,# 51,p. 16318 - 16322][Angew. Chem.,2017,vol. 129,# 51,p. 16536 - 16540,5]
110-83-8
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108-95-2
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119-42-6
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35406-29-2
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1131-60-8
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92-69-3
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1131-60-8
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108-93-0
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108-95-2
796 suppliers
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119-42-6
94 suppliers
$27.00/5g
35406-29-2
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inquiry
1131-60-8
196 suppliers
$9.00/5g
108-93-0
449 suppliers
$11.00/25g
108-95-2
796 suppliers
$14.00/25g
119-42-6
94 suppliers
$27.00/5g
1131-60-8
196 suppliers
$9.00/5g