8-PENTADECANONE synthesis
- Product Name:8-PENTADECANONE
- CAS Number:818-23-5
- Molecular formula:C15H30O
- Molecular Weight:226.4
13125-66-1
110 suppliers
$60.00/5g
200886-71-1
7 suppliers
inquiry
818-23-5
81 suppliers
$45.00/500mg
Yield:818-23-5 65%
Reaction Conditions:
in tetrahydrofuran at 0 - 20; for 4 h;Inert atmosphere;Solvent;
Steps:
5.2 ATX-81: Step 2
To a solution of 22 g heptyl magnesium bromide (1.5 eq.) in THF (100 ml), taken in a 1 liter, two neck round bottom flask, stirred at 0° C. under nitrogen atmosphere, was added N-methoxy-N-methyloctanamide (1 eq.) solution (dissolved in 200 ml THF) and the resulting reaction mixture was stirred at room temperature for 4 hours. Progress of the reaction was monitored by TLC (10% EtOAc in hexane; Rf: 0.7). Reaction mass was quenched with saturated NH4Cl solution (250 ml) and then EtOAc (350 ml) was added. The organic layer was separated and the aqueous layer was washed with EtOAc (2×100 ml). Combined organic layers were concentrated under reduced pressure. Crude compound was subjected to column chromatography using (60-120 mesh silica gel; 2% EtOAc/hexane). Quantity produced, 22 g; yield, 65%.
References:
Arcturus Therapeutics, Inc.;Payne, Joseph E.;Chivukula, Padmanabh;Karmali, Priya;Tanis, Steven P. US2018/169268, 2018, A1 Location in patent:Paragraph 0022; 0254-0256; 0418
124-07-2
771 suppliers
$6.00/25g
57-11-4
1326 suppliers
$6.00/100g
818-23-5
81 suppliers
$45.00/500mg
124-07-2
771 suppliers
$6.00/25g
818-23-5
81 suppliers
$45.00/500mg
821-55-6
338 suppliers
$7.00/25g
111-87-5
798 suppliers
$6.00/100g
818-23-5
81 suppliers
$45.00/500mg
124-07-2
771 suppliers
$6.00/25g
57-11-4
1326 suppliers
$6.00/100g
818-23-5
81 suppliers
$45.00/500mg
821-55-6
338 suppliers
$7.00/25g
928-80-3
90 suppliers
$50.00/1 SAMPLE-K