p-Toluenethiol synthesis
- Product Name:p-Toluenethiol
- CAS Number:106-45-6
- Molecular formula:C7H8S
- Molecular Weight:124.2
624-31-7
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106-45-6
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Yield:106-45-6 99%
Reaction Conditions:
with copper(ll) sulfate pentahydrate;ethane-1,2-dithiol;potassium hydroxide in water;dimethyl sulfoxide at 90; for 20 h;Inert atmosphere;Temperature;Solvent;Reagent/catalyst;
Steps:
1; 2 Experimental Example 2: Yield analysis of arylthiol synthesized using various thiols
General procedure: A test tube equipped with a magnetic stir bar was charged with an aryl halide(aryl halide, 1 mmol),CuSO4.5H2O(12.5 mg, 0.05 mmol),KOH (280 mg, 5 mmol) orCs2CO3 (1.62 g, 5 mmol), DMSO (2 mL), and water (0.2 mL; water was not used in case of using Cs2CO3 as base).After flushing with argon, 1,2-ethanedithiol (0.18 mL, 2 mmol) was added.The mixture was heated in a preheated oil bath for 20 hours90 ° C or 110 ° C bath which is pre-heated with agitation.After cooling to ambient temperature, the reaction mixture was distributed in aqueous HCl (5%) and ethyl acetate. The organic layer was washed with water and brine, dried over anhydrous MgSO4 and concentrated in vacuo. The crude product was purified by column chromatography (EtOAc / n-Hexane) to give the aryl thiol (see Table 2 below).
References:
SUNGSHIN WOMEN`S UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION;CHAE, Junghyun;Liu, Ya jun;KIM, Ji hye KR2017/76524, 2017, A Location in patent:Paragraph 0032; 0033; 0056-0060
106-43-4
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106-45-6
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106-38-7
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106-45-6
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103-19-5
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106-45-6
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98-59-9
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106-45-6
228 suppliers
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