Propylparaben synthesis
- Product Name:Propylparaben
- CAS Number:94-13-3
- Molecular formula:C10H12O3
- Molecular Weight:180.2
Yield:94-13-3 93.4%
Reaction Conditions:
with methanesulfonic acid;trimethyl-(2-hydroxyethyl)ammonium chlorideReflux;
Steps:
3.1; 3.2; 3.3 Example 3 Preparation of parabens:
In the first step, 1 mol of choline chloride and 2 mol of methanesulfonic acid were added to the reaction vessel, and the mixture was stirred at 80 ° C until the total dissolution was low. Co-melting solvent;In the second step, after cooling the reaction system to room temperature, 1 mol of p-hydroxybenzoic acid and 1.2 mol of n-propanol are added, the temperature is slowly raised, and the reaction is refluxed, and TLC is monitored until the end of the reaction;In the third step, the reaction solution is cooled to room temperature, a solid is precipitated, suction filtration, and the filter cake is washed with a small amount of water.The paraben was obtained, the yield was 93.4%, m.p. 96-97 ° C; the filtrate was recovered to obtain a eutectic solvent.
References:
CN109970557,2019,A Location in patent:Paragraph 0042; 0043; 0044; 0045; 0046; 0047; 0048
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